ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2013
Role of chelation in the treatment of lead poisoning: discussion of the Treatment of Lead-Exposed Children Trial (TLC).
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Heavy Metal Toxicity in Clinical and Environmental Health: Sources, Mechanisms, Diagnostics, and Evidence-Based Management of Mercury, Lead, Cadmium, and Arsenic.International journal of molecular sciences · 2026Review
- Case series: from ventilation failure to substitution success in occupational lead poisoning at a Korean indoor firing range.Annals of occupational and environmental medicine · 2026Article
- Group-I lead oxide XRSC advances · 2025Article
- The effect of chelation on bone Pb stores in Pb poisoned children.Journal of exposure science & environmental epidemiology · 2025Article
- Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice.Molecules (Basel, Switzerland) · 2022Article
- Blood Lead Levels, Hemoglobin, and Liver Enzymes in Opium-Dependent Addicts.International journal of preventive medicine · 2021Article
- (Ascorb)ing Pb Neurotoxicity in the Developing Brain.Antioxidants (Basel, Switzerland) · 2020Review
- The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress.PloS one · 2019Article
- Evaluation and management of lead exposure.Annals of occupational and environmental medicine · 2015Review
- Current use of chelation in American health care.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2013Review
- Medical toxicology case presentations: to chelate or not to chelate, is that the question?Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Lead exposure in children is one component leading to cognitive impairment. The Treatment of Lead-Exposed Children Trial (1994-2004) studied the effect of succimer in treating low levels of lead exposure (20-44 mcg/dL) in children 12 to 33 months old. While succimer was effective in reducing blood lead concentrations in the short term, treatment of blood lead levels did not result in any detectable improvement in a wide variety of measurements of cognitive or behavioral function. Furthermore, blood lead concentrations were not distinguishable between chelated and non-chelated individuals at 1 year. The most important treatment strategy is identification and termination of major sources of lead exposure.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.