ArticleAmino acids1996
CATs, a family of three distinct mammalian cationic amino acid transporters.
Article in Amino acids, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 69 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Harnessing amino acid pathways to influence myeloid cell function in tumor immunity.Molecular medicine (Cambridge, Mass.) · 2025Review
- Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells.Science advances · 2023Article
- Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives.Amino acids · 2022Article
- Arginine-dependent immune responses.Cellular and molecular life sciences : CMLS · 2021Review
- Transport of L-Arginine Related Cardiovascular Risk Markers.Journal of clinical medicine · 2020Review
- Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension.Physiological reviews · 2019Review
- Expression Profile of Cationic Amino Acid Transporters in Rats with Endotoxin-Induced Uveitis.Mediators of inflammation · 2016Article
- Identification and functional characterization of a novel arginine/ornithine transporter, a member of a cationic amino acid transporter subfamily in the Trypanosoma cruzi genome.Parasites & vectors · 2015Article
- Heparin normalizes allergen-induced nitric oxide deficiency and airway hyperresponsiveness.British journal of pharmacology · 2004Article
- Inhibition of nitric oxide synthase abrogates lipopolysaccharides-induced up-regulation of L-arginine uptake in rat alveolar macrophages.British journal of pharmacology · 2001Article
- The transport activity of the human cationic amino acid transporter hCAT-1 is downregulated by activation of protein kinase C.British journal of pharmacology · 2001Article
- Activation of L-arginine transport by protein kinase C in rabbit, rat and mouse alveolar macrophages.The Journal of physiology · 1998Article
- Regulation of CAT: Cationic amino acid transporter gene expression.Amino acids · 1996Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three related mammalian carrier proteins that mediate the transport of cationic amino acids through the plasma membrane have been identified in murine and human cells (CAT for cationic amino acid transporter). Models of the CAT proteins in the membrane suggest they have 12 or 14 transmembrane domains connected by short hydrophilic loops and intracellular N- and C-termini. The transport activity of the CAT proteins is sensitive to trans-stimulation and independent of the presence of sodium ions. These features agree with the behaviour of carrier proteins mediating facilitated diffusion. The three CAT proteins, CAT-1, CAT-2A and CAT-2(B) are encoded by two different genes (CAT-1 and CAT-2). CAT-1 and CAT-2(B) exhibit transport properties consistent with system y(+), the principal mechanism for cellular uptake of cationic amino acids. In contrast, CAT-2A has tenfold lower substrate affinity, greater apparent maximal velocity and it is much less sensitive to trans-stimulation. In addition to structural and functional aspects, this review discusses the role of the CAT proteins for supplying substrate to NO synthases and the property of the rodent CAT-1 proteins to function as virus receptors.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.