Trial reportPrevention science : the official journal of the Society for Prevention Research2014
Reducing aggression and impulsivity through school-based prevention programs: a gene by intervention interaction.
Trial report in Prevention science : the official journal of the Society for Prevention Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 61 citations in OpenAlex.
- Evaluating the genetic susceptibility to peer reported bullying behaviors.Psychiatry research · 2018Trial
- Impulsivity profiles across five harmonized longitudinal childhood preventive interventions and associations with adult outcomes.Development and psychopathology · 2025Article
- A person-centered data analytic approach to dopaminergic polygenic moderation of child maltreatment exposure.Developmental psychobiology · 2023Article
- Does pre-COVID impulsive behaviour predict adherence to hygiene and social distancing measures in youths following the COVID-19 pandemic onset? Evidence from a South African longitudinal study.BMC public health · 2023Article
- Identifying moderating factors during the preschool period in the development of borderline personality disorder: a prospective longitudinal analysis.Borderline personality disorder and emotion dysregulation · 2022Article
- Association between hypomania and self-harm behaviors in Chinese children and adolescents with depressive symptoms.Frontiers in psychiatry · 2022Article
- Impulsivity mediates the association between parenting styles and self-harm in Chinese adolescents.BMC public health · 2021Article
- Scaling up and scaling out: Consilience and the evolution of more nurturing societies.Clinical psychology review · 2020Review
- MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice.Molecular therapy. Nucleic acids · 2020Article
- A Review of Mental Health and Mental Health Care Disparities Research: 2011-2014.Medical care research and review : MCRR · 2019Review
- Aggression and its predictors among elementary students.Journal of injury & violence research · 2019Article
- Neuroplasticity of selective attention: Research foundations and preliminary evidence for a gene by intervention interaction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Developmental Patterns of Adolescent Marijuana and Alcohol Use and Their Joint Association with Sexual Risk Behavior and Outcomes in Young Adulthood.Journal of urban health : bulletin of the New York Academy of Medicine · 2017Article
- Adverse Childhood Experiences and Suicide Attempts: The Mediating Influence of Personality Development and Problem Behaviors.Journal of youth and adolescence · 2016Article
- An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A variety of school-based, universal preventive interventions have been developed to address behavioral and mental health problems. Unfortunately, few have been evaluated within the context of randomized controlled trials with long-term follow-up. Even fewer still have examined the potential genetic factors that may drive differential impact of the intervention. In the present analysis, we examine the extent to which the longitudinal effects of two elementary school-based interventions were moderated by the brain-derived neurotrophic factor (BDNF) gene, which has been linked with aggression and impulsive behaviors. The sample included 678 urban, primarily African American children who were randomly assigned along with their teachers to one of three first grade classroom conditions: classroom-centered (CC) intervention, Family School Partnership (FSP), or a control condition. The teacher ratings of the youth's aggressive and impulsive behavior were obtained at baseline and in grades 6-12. Single-nucleotide polymorphisms (SNPs) from the BDNF gene were extracted from the genome-wide data. Longitudinal latent trait-state-error models indicated a significant interaction between a particular profile of the BDNF SNP cluster (46 % of sample) and CC intervention on impulsivity (β = -.27, p < .05). A similar interaction was observed for the BDNF SNP cluster and the CC intervention on aggression (β = -.14, p < .05). The results suggest that the impacts of preventive interventions in early elementary school on late adolescent outcomes of impulsivity and aggression can be potentially modified by genetic factors, such as BDNF. However, replication of these results is necessary before firm conclusions can be drawn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.