ReviewJournal of neural transmission (Vienna, Austria : 1996)2014
Neuronal gap junction coupling as the primary determinant of the extent of glutamate-mediated excitotoxicity.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Transient entanglement in minimal open XXZ spin chains: a toy-model analogy for microtubule-inspired quantum biology.Frontiers in psychiatry · 2026Article
- Neuroprotective gap-junction-mediated bystander transformations in the adult zebrafish spinal cord after injury.Nature communications · 2024Article
- Increased RNA Transcription of Energy Source Transporters in Circulating White Blood Cells of Aged Mice.Frontiers in aging neuroscience · 2022Article
- Ouabain Enhances Gap Junctional Intercellular Communication by Inducing Paracrine Secretion of Prostaglandin E2.International journal of molecular sciences · 2021Article
- Prostaglandin E2 Enhances Gap Junctional Intercellular Communication in Clonal Epithelial Cells.International journal of molecular sciences · 2021Article
- Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes.Cellular and molecular neurobiology · 2021Article
- Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions.Neuroscience · 2021Review
- Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36.Cell death & disease · 2017Article
- Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.BMC cell biology · 2017Review
- The Features and Functions of Neuronal Assemblies: Possible Dependency on Mechanisms beyond Synaptic Transmission.Frontiers in neural circuits · 2016Review
- Role of neuronal gap junctions in NMDA receptor-mediated excitotoxicity and ischemic neuronal death.Neural regeneration research · 2016Article
- Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?Cellular and molecular life sciences : CMLS · 2015Review
- Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin.PloS one · 2015Article
- Roles of gap junctions, connexins, and pannexins in epilepsy.Frontiers in physiology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (electrical synapses) increases during early postnatal development, then decreases, but increases in the mature CNS following neuronal injury, such as ischemia, traumatic brain injury and epilepsy. Glutamate-dependent neuronal death also occurs in the CNS during development and neuronal injury, i.e., at the time when neuronal gap junction coupling is increased. Here, we review our recent studies on regulation of neuronal gap junction coupling by glutamate in developing and injured neurons and on the role of gap junctions in neuronal cell death. A modified model of the mechanisms of glutamate-dependent neuronal death is discussed, which includes neuronal gap junction coupling as a critical part of these mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.