Evidence map›Paper›PMID 24178185›Full record

Trial reportWorld journal of surgery2014

Perioperative immunonutrition in surgical cancer patients: a summary of a decade of research.

Stanislaw Klek, Piotr Szybinski, Kinga Szczepanek

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06128798 (A Randomized Controlled Trial on Effect of Preoperative Immunonutrition Versus Standard Oral Nutrition in Patient Undergoing Colorectal Surgery.), which is not on this map. Cited by 36 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06128798 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomized Controlled Trial on Effect of Preoperative Immunonutrition Versus Standard Oral Nutrition in Patient Undergoing Colorectal Surgery.

TypeinterventionalSponsorHospital Universiti Sains MalaysiaRan2023 to 2024Enrolled58ConditionsColorectal NeoplasmsArmsOral Impact, Nutren Optimum
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Postoperative nutritional support after pancreaticoduodenectomy in adults.The Cochrane database of systematic reviews · 2025
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  9. Enteral and parenteral nutrition in cancer patients, a comparison of complication rates: an updated systematic review and (cumulative) meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  14. Article
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  17. Review
  18. Effects of preoperative immunonutritionWorld journal of gastrointestinal surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stanislaw KlekGeneral and Oncological Surgery Unit, Stanley Dudrick's Memorial Hospital, 15 Tyniecka Street, 32-050, Skawina, Poland, klek@poczta.onet.pl.
Piotr Szybinski
Kinga Szczepanek

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunonutrition is assumed to enhance immune system function. In surgical patients, it is supposed to reduce postoperative complications. However, results of recent clinical trials have been puzzling and have not supported this theory.

aimThe aim of our study was to evaluate the value of enteral and parenteral postoperative immunonutrition.

methodsAfter initial evaluation of 969 patients, the intent-to-treat analysis included 776 patients (female 407, male 466, mean age 61.1 years) undergoing gastric or pancreatic resections between 2001 and 2009. All patients were randomly assigned after surgery to one of the following groups: standard enteral nutrition (SEN), immunomodulating enteral nutrition (IMEN), standard parenteral nutrition (SPN), or immunomodulating parenteral nutrition (IMPN). All malnourished patients received preoperative parenteral nutrition. Number and type of postoperative complications, length of hospitalization (length of stay [LOS]), and vital organ function were assessed.

resultsNo statistically significant differences were observed in well-nourished patients, during either enteral or parenteral intervention, independent of the type of intervention (standard or immunomodulating). However, analysis of the malnourished group revealed the positive impact of enteral immunonutrition on reduction of postoperative complications (28.3 vs. 39.2 %, respectively; p = 0.043) and LOS (17.1 and 13.1 days, respectively; p < 0.05) compared with a standard enteral diet. The cross-analysis of SEN, IMEN, SPN, and IMPN was insignificant.

conclusionsThe type of postoperative nutrition was of no importance in well-nourished patients. However, in malnourished patients, enteral immunonutrition helped to improve treatment outcome. These findings suggest its use as a method of choice during the postoperative period.

Indexed as

ImmunomodulationAgedEnteral NutritionFemaleFollow-Up StudiesGastrectomyHumansIntention to Treat AnalysisLength of StayMaleMiddle AgedPancreatectomyParenteral NutritionPostoperative CarePostoperative ComplicationsTreatment Outcome

Identifiers

PMID24178185
PMCPMC3956976

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.