ArticleJournal of pharmacokinetics and pharmacodynamics2013
Solution and implementation of distributed lifespan models.
Article in Journal of pharmacokinetics and pharmacodynamics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Quantitative Systems Pharmacology: A Framework for Context.Current pharmacology reports · 2016Article
- Pharmacodynamic models of age-structured cell populations.Journal of pharmacokinetics and pharmacodynamics · 2015Review
- Modeling of delays in PKPD: classical approaches and a tutorial for delay differential equations.Journal of pharmacokinetics and pharmacodynamics · 2014Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We consider a population where every individual has a unique lifespan. After expiring of its lifespan the individual has to leave the population. A realistic approach to describe these lifespans is by a continuous distribution. Such distributed lifespan models (DLSMs) were introduced earlier in the indirect response context and consist of the mathematical convolution operator to describe the rate of change. Therefore, DLSMs could not directly be implemented in standard PKPD software. In this work we present the solution representation of DLSMs with and without a precursor population and an implementation strategy for DLSMs in ADAPT , NONMEM and MATLAB . We fit hemoglobin measurements from literature and investigate computational properties.
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Registered trials
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