ReviewApplied microbiology and biotechnology2013
ω3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use.
Review in Applied microbiology and biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Enhanced DHA Production inMarine drugs · 2026Article
- Freshwater-adapted polychaetes exhibit a complete enzymatic machinery for synthesizing long-chain polyunsaturated fatty acids.Open biology · 2025Article
- Dietary supplementing South African indigenous rams with flaxseed oil and ascorbic acid improves cryopreserved semen quality and in vitro fertility.Tropical animal health and production · 2024Article
- Microalgae as Raw Materials for Aquafeeds: Growth Kinetics and Improvement Strategies of Polyunsaturated Fatty Acids Production.Aquaculture nutrition · 2023Review
- Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture.Applied microbiology and biotechnology · 2022Review
- NADPH-Cytochrome P450 Reductase Mediates the Fatty Acid Desaturation of ω3 and ω6 Desaturases fromCurrent issues in molecular biology · 2022Article
- Impact of Tween 80 on Fatty Acid Composition in Two Bacterial Species.Archives of Razi Institute · 2021Article
- Temperature Acclimation of the PicoalgaFrontiers in plant science · 2021Article
- Plastidic Δ6 Fatty-Acid Desaturases with Distinctive Substrate Specificity Regulate the Pool of C18-PUFAs in the Ancestral PicoalgaPlant physiology · 2020Article
- Unique fatty acid desaturase capacities uncovered inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Endoplasmic reticulum retention signaling and transmembrane channel proteins predicted for oilseed ω3 fatty acid desaturase 3 (FAD3) genes.Functional & integrative genomics · 2020Article
- NovelMarine drugs · 2020Article
- Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids.Biotechnology for biofuels · 2020Article
- Overexpression of △12, △15-Desaturases for Enhanced Lipids Synthesis inFrontiers in microbiology · 2020Article
- Comparison of the Substrate Preferences of ω3 Fatty Acid Desaturases for Long Chain Polyunsaturated Fatty Acids.International journal of molecular sciences · 2019Article
- Characterization and molecular docking of new Δ17 fatty acid desaturase genes fromRSC advances · 2019Article
- The Nematode Caenorhabditis elegans as a Model Organism to Study Metabolic Effects of ω-3 Polyunsaturated Fatty Acids in Obesity.Advances in nutrition (Bethesda, Md.) · 2019Review
- Homology modeling and docking studies of a Δ9-fatty acid desaturase from a Cold-tolerantPeerJ · 2018Article
- Substrate specificity and membrane topologies of the iron-containing ω3 and ω6 desaturases from Mortierella alpina.Applied microbiology and biotechnology · 2018Article
- Three, two, one yeast fatty acid desaturases: regulation and function.World journal of microbiology & biotechnology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The biosynthesis of very-long-chain polyunsaturated fatty acids involves an alternating process of fatty acid desaturation and elongation catalyzed by complex series of enzymes. ω3 desaturase plays an important role in converting ω6 fatty acids into ω3 fatty acids. Genes for this desaturase have been identified and characterized in a wide range of microorganisms, including cyanobacteria, yeasts, molds, and microalgae. Like all fatty acid desaturases, ω3 desaturase is structurally characterized by the presence of three highly conserved histidine-rich motifs; however, unlike some desaturases, it lacks a cytochrome b5-like domain. Understanding the structure, function, and evolution of ω3 desaturases, particularly their substrate specificities in the biosynthesis of very-long-chain polyunsaturated fatty acids, lays the foundation for potential production of various ω3 fatty acids in transgenic microorganisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.