Evidence map›Paper›PMID 24177145›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2013

Deriving comorbidities from medical records using natural language processing.

Hojjat Salmasian, Daniel E Freedberg, Carol Friedman

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Antibiotic-Specific Risk for Community-AcquiredAntimicrobial agents and chemotherapy · 2022
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  15. Defining Phenotypes from Clinical Data to Drive Genomic Research.Annual review of biomedical data science · 2018
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  20. Interpretable Topic Features for Post-ICU Mortality Prediction.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hojjat SalmasianDepartment of Biomedical Informatics, Columbia University, New York, USA.
Daniel E Freedberg
Carol Friedman

Funding

Training in Biomedical Informatics at Columbia UniversityT15LM007079 · NLM · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI NOEMIE ELHADAD, GEORGE M HRIPCSAK · 1992 to 2026
$28.9M
Multidisciplinary Training in Translational Gastrointestinal and Liver ResearchT32DK083256 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2009 to 2026
$5.5M
Pharmacovigilence using Natural Language Processing, Statistics, and the EHRR01LM010016 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FRIEDMAN, CAROL · 2009 to 2016
$3.4M
A Biomedical Natural Language Processing ResourceR01LM008635 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FRIEDMAN, CAROL · 2005 to 2008
$2.1M
NIDDK NIH HHS T32 DK083256NIDDK NIH HHS T32 DK083256-04NLM NIH HHS 5 T15 LM007079NLM NIH HHS R01 LM008635NLM NIH HHS R01 LM010016NLM NIH HHS R01 LM010016-0S1NLM NIH HHS R01 LM010016-0S2NLM NIH HHS T15 LM007079
6 · The paper itself

Abstract

Extracting comorbidity information is crucial for phenotypic studies because of the confounding effect of comorbidities. We developed an automated method that accurately determines comorbidities from electronic medical records. Using a modified version of the Charlson comorbidity index (CCI), two physicians created a reference standard of comorbidities by manual review of 100 admission notes. We processed the notes using the MedLEE natural language processing system, and wrote queries to extract comorbidities automatically from its structured output. Interrater agreement for the reference set was very high (97.7%). Our method yielded an F1 score of 0.761 and the summed CCI score was not different from the reference standard (p=0.329, power 80.4%). In comparison, obtaining comorbidities from claims data yielded an F1 score of 0.741, due to lower sensitivity (66.1%). Because CCI has previously been validated as a predictor of mortality and readmission, our method could allow automated prediction of these outcomes.

Indexed as

ComorbidityElectronic Health RecordsNatural Language ProcessingAdolescentAdultAgedAged, 80 and overChildChild, PreschoolDiabetes ComplicationsFemaleHumansInfantMaleMiddle AgedReference StandardsComorbidityConfounding FactorsNatural Language Processing

Identifiers

PMID24177145
PMCPMC3861932

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.