Evidence map›Paper›PMID 24177013›Full record

ReviewBiochemical and biophysical research communications2013

Relevance of signaling molecules for apoptosis induction on influenza A virus replication.

Atsushi Iwai, Takuya Shiozaki, Tadaaki Miyazaki

Open access · greenAbstract readReview
In one paragraph

Review in Biochemical and biophysical research communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Atsushi IwaiAureo Science Co., Ltd., North 21, West 12, Kita-Ku, Sapporo, Hokkaido 001-0021, Japan.
Takuya Shiozaki
Tadaaki Miyazaki
Hokkaido University · JPAureo (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apoptosis is an important mechanism to maintain homeostasis in mammals, and disruption of the apoptosis regulation mechanism triggers a range of diseases, such as cancer, autoimmune diseases, and developmental disorders. The severity of influenza A virus (IAV) infection is also closely related to dysfunction of apoptosis regulation. In the virus infected cells, the functions of various host cellular molecules involved in regulation of induction of apoptosis are modulated by IAV proteins to enable effective virus replication. The modulation of the intracellular signaling pathway inducing apoptosis by the IAV infection also affects extracellular mechanisms controlling apoptosis, and triggers abnormal host responses related to the disease severity of IAV infections. This review focuses on apoptosis related molecules involved in IAV replication and pathogenicity, the strategy of the virus propagation through the regulation of apoptosis is also discussed.

Indexed as

ApoptosisVirus ReplicationCaspase 3DEAD Box Protein 58DEAD-box RNA HelicasesHumansInfluenza A virusReceptors, Death DomainReceptors, ImmunologicSignal TransductionCaspase 3DEAD Box Protein 58DEAD-box RNA HelicasesReceptors, Death DomainReceptors, ImmunologicRIGI protein, humanAktApaf-1Apoptosisapoptotic protease activating factor 1BaxB-cell lymphoma 2Bcl-2Bcl-2-associated x proteinBcl-2 homologyBHCaspasesc-Jun amino-terminal kinasecysteine–aspartic acid proteaseDAP3death-associated protein 3death receptor 4death receptor 5DR4DR5FADDFas-associated death domainIAVIFNIFN regulatory factor 3influenza A virusInfluenza A virusINF-β promoter stimulator protein 1interferonIPS-1IRF3JNKMmatrix proteinNAneuraminidaseNF-κBnon-structural protein 1NPNS1nuclear factor-κBnucleoproteinphosphatidylinositol-3 kinasePI3Kretinoic acid-inducible gene-IRIG-ISignal transductionTNF-related apoptosis inducing ligandTNF-αTNFαR1TNF-α receptor 1TRADDTRAILtumor necrosis factor receptor type 1-associated death domain proteintumor necrosis factor αv-akt murine thymoma viral oncogene homolog 1XIAPX-linked inhibitor of apoptosis proteinZAPSzinc finger antiviral protein, short form

Identifiers

PMID24177013
PMCPMC7092955
OpenAlexW2055734000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.