ReviewAdvances in biological regulation2014
Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes.
Review in Advances in biological regulation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Phosphoinositides and inositol phosphates as molecular glues.FEBS letters · 2026Review
- Potential endogenous lipid ligands for the nuclear receptor transcription factor Steroidogenic Factor-1.Advances in biological regulation · 2026Review
- Expression and purification of Steroidogenic Factor-1 (NR5A1) nuclear receptor ligand binding domain complexed with the signaling phosphoinositide lipid PI(3,4,5)PMethods in enzymology · 2026Article
- SF-1 Induces Nuclear PIP2.Biomolecules · 2023Article
- Article
- USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.Molecular oncology · 2022Article
- The phosphoinositide regulatory network in Trypanosoma brucei: Implications for cell-wide regulation in eukaryotes.PLoS neglected tropical diseases · 2020Review
- Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease.Journal of lipid research · 2019Review
- Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism.Advances in biological regulation · 2019Review
- Nuclear phosphoinositide regulation of chromatin.Journal of cellular physiology · 2018Review
- The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub.Molecules and cells · 2017Review
- Nuclear Lipids in the Nervous System: What they do in Health and Disease.Neurochemical research · 2017Review
- Phospholipid regulation of the nuclear receptor superfamily.Advances in biological regulation · 2017Review
- Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism.Biochemical Society transactions · 2016Review
- IQGAP1 is a phosphoinositide effector and kinase scaffold.Advances in biological regulation · 2016Review
- The Breast Cancer Susceptibility Gene Product (γ-Synuclein) Alters Cell Behavior through its [corrected] Interaction with Phospholipase Cβ.Cellular signalling · 2016Article
- Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.Advances in biological regulation · 2016Article
- Phosphoinositide-specific phospholipase C in health and disease.Journal of lipid research · 2015Review
- PTEN: Multiple Functions in Human Malignant Tumors.Frontiers in oncology · 2015Review
- The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
An unresolved problem in biological signal transduction is how particular branches of highly interconnected signaling networks can be decoupled, allowing activation of specific circuits within complex signaling architectures. Although signaling dynamics and spatiotemporal mechanisms serve critical roles, it remains unclear if these are the only ways cells achieve specificity within networks. The transcription factor Steroidogenic Factor-1 (SF-1) is an excellent model to address this question, as it forms dynamic complexes with several chemically distinct lipid species (phosphatidylinositols, phosphatidylcholines and sphingolipids). This property is important since lipids bound to SF-1 are modified by lipid signaling enzymes (IPMK & PTEN), regulating SF-1 biological activity in gene expression. Thus, a particular SF-1/lipid complex can interface with a lipid signaling enzyme only if SF-1 has been loaded with a chemically compatible lipid substrate. This mechanism permits dynamic downstream responsiveness to constant upstream input, disentangling specific pathways from the full network. The potential of this paradigm to apply generally to nuclear lipid signaling is discussed, with particular attention given to the nuclear receptor superfamily of transcription factors and their phospholipid ligands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.