Evidence map›Paper›PMID 24176725›Full record

ArticleActa biomaterialia2014

Biological magnetic cellular spheroids as building blocks for tissue engineering.

Brandon Mattix, Timothy R Olsen, Yu Gu, Megan Casco, Austin Herbst, Dan T Simionescu, Richard P Visconti, Konstantin G Kornev, Frank Alexis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  12. Advanced Multi-Dimensional Cellular Models as Emerging Reality to ReproduceInternational journal of molecular sciences · 2021
    Review
  13. Review
  14. Article
  15. Magnetoferritin: Process, Prospects, and Their Biomedical Applications.International journal of molecular sciences · 2019
    Review
  16. Progress in scaffold-free bioprinting for cardiovascular medicine.Journal of cellular and molecular medicine · 2018
    Review
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brandon MattixDepartment of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC 29634, USA.
Timothy R OlsenDepartment of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC 29634, USA.
Yu GuDepartment of Materials Science and Engineering, Clemson University, 161 Sirrine Hall, Clemson, SC 29634, USA.
Megan CascoDepartment of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC 29634, USA.
Austin HerbstDepartment of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC 29634, USA.
Dan T SimionescuDepartment of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC 29634, USA.
Richard P ViscontiDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, BSB 601, Charleston, SC 29425, USA.
Konstantin G KornevDepartment of Materials Science and Engineering, Clemson University, 161 Sirrine Hall, Clemson, SC 29634, USA.
Frank AlexisDepartment of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC 29634, USA; Institute of Biological Interfaces of Engineering, 401-2 Rhodes Engineering Research Center, Clemson, SC 29634, USA. Electronic address: falexis@clemson.edu.

Funding

UNDERSTANDING AND CONTROLLING TISSUE-SPECIFIC VASCULAR PATTERNINGP20RR021949 · NCRR · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R · 2009 to 2011
$5.2M
Elastin-derived Scaffolds for Tissue Engineered Small Diameter Vascular GraftsR03TW008941 · FIC · CLEMSON UNIVERSITY · PI SIMIONESCU, DAN TEODOR · 2011 to 2013
$169k
FIC NIH HHS R03 TW008941NCRR NIH HHS P20 RR021949
6 · The paper itself

Abstract

Magnetic nanoparticles (MNPs), primarily iron oxide nanoparticles, have been incorporated into cellular spheroids to allow for magnetic manipulation into desired shapes, patterns and 3-D tissue constructs using magnetic forces. However, the direct and long-term interaction of iron oxide nanoparticles with cells and biological systems can induce adverse effects on cell viability, phenotype and function, and remain a critical concern. Here we report the preparation of biological magnetic cellular spheroids containing magnetoferritin, a biological MNP, capable of serving as a biological alternative to iron oxide magnetic cellular spheroids as tissue engineered building blocks. Magnetoferritin NPs were incorporated into 3-D cellular spheroids with no adverse effects on cell viability up to 1 week. Additionally, cellular spheroids containing magnetoferritin NPs were magnetically patterned and fused into a tissue ring to demonstrate its potential for tissue engineering applications. These results present a biological approach that can serve as an alternative to the commonly used iron oxide magnetic cellular spheroids, which often require complex surface modifications of iron oxide NPs to reduce the adverse effects on cells.

Indexed as

Magnetic PhenomenaAnimalsApoferritinsCattleCell SurvivalHorsesIronMagnetite NanoparticlesOxidesRatsSpheroids, CellularTissue EngineeringApoferritinsIronMagnetite NanoparticlesmagnetoferritinOxidesFerritinMagnetic nanoparticlesMagnetoferritinTissue engineering

Identifiers

PMID24176725
PMCPMC4733563

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.