ArticleEpilepsy & behavior : E&B2013
Alterations in functional connectivity between the hippocampus and prefrontal cortex as a correlate of depressive symptoms in temporal lobe epilepsy.
Article in Epilepsy & behavior : E&B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 47 citations in OpenAlex.
- Detrended fluctuation analysis of amygdala-hippocampal beta synchrony reveals network rigidity in depression associated with temporal lobe epilepsy.Journal of neural engineering · 2026Article
- Cenobamate's effect on mood and seizure frequency.Epilepsy & behavior : E&B · 2026Article
- A pilot study of inter-regional phase amplitude coupling as comorbid depression biomarker in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2025Article
- Article
- Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies.Network neuroscience (Cambridge, Mass.) · 2022Article
- Thresholding Functional Connectivity Matrices to Recover the Topological Properties of Large-Scale Neuronal Networks.Frontiers in neuroscience · 2021Article
- Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies.Frontiers in human neuroscience · 2021Article
- Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging.Frontiers of medicine · 2020Article
- Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity.Epilepsy & behavior : E&B · 2020Article
- Depression and Anxiety in the Epilepsies: from Bench to Bedside.Current neurology and neuroscience reports · 2020Review
- Review
- Temporal plus epilepsy: Anatomo-electroclinical subtypes.Iranian journal of neurology · 2016Article
- Subregional Mesiotemporal Network Topology Is Altered in Temporal Lobe Epilepsy.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea.Neuropsychiatric disease and treatment · 2016Article
- Temporal lobe epilepsy and affective disorders: the role of the subgenual anterior cingulate cortex.Journal of neurology, neurosurgery, and psychiatry · 2015Article
- Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems.Metabolic brain disease · 2015Article
- Frontolimbic brain networks predict depressive symptoms in temporal lobe epilepsy.Epilepsy research · 2014Article
- Functional network alterations and their structural substrate in drug-resistant epilepsy.Frontiers in neuroscience · 2014Review
- Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions.Epilepsy currentsArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Depression is a common comorbidity in temporal lobe epilepsy (TLE) that is thought to have a neurobiological basis. This study investigated the functional connectivity (FC) of medial temporal networks in depression symptomatology of TLE and the relative contribution of structural versus FC measures. Volumetric MRI and functional connectivity MRI (fcMRI) were performed on nineteen patients with TLE and 20 controls. The hippocampi and amygdalae were selected as seeds, and five prefrontal and five cingulate regions of interest (ROIs) were selected as targets. Low-frequency blood-oxygen-level-dependent signals were isolated from fcMRI data, and ROIs with synchronous signal fluctuations with the seeds were identified. Depressive symptoms were measured by the Beck Depression Inventory-II. The patients with TLE showed greater ipsilateral hippocampal atrophy (HA) and reduced FC between the ipsilateral hippocampus and the ventral posterior cingulate cortex (vPCC). Neither HA nor hippocampal-vPCC FC asymmetry was a robust contributor to depressive symptoms. Rather, hippocampal-anterior prefrontal FC was a stronger contributor to depressive symptoms in left TLE (LTLE). Conversely, right amygdala FC was correlated with depressive symptoms in both patient groups, with a positive and negative correlation in LTLE and right TLE (RTLE), respectively. Frontolimbic network dysfunction is a strong contributor to levels of depressive symptoms in TLE and a better contributor than HA in LTLE. In addition, the right amygdala may play a role in depression symptomatology regardless of the side of the epileptogenic focus. These findings may inform the treatment of depressive symptoms in TLE and inspire future research to help guide surgical planning.
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