ArticleSchizophrenia research2013
Altered language network activity in young people at familial high-risk for schizophrenia.
Article in Schizophrenia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Brain-Wide Analysis of Functional Connectivity in First-Episode and Chronic Stages of Schizophrenia.Schizophrenia bulletin · 2017Pooled it
- Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia.Frontiers in psychiatry · 2024Article
- Cerebral blood flow changes in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment.European archives of psychiatry and clinical neuroscience · 2023Article
- Disembodiment and Language in Schizophrenia: An Integrated Psychopathological and Evolutionary Perspective.Schizophrenia bulletin · 2023Article
- Historical pursuits of the language pathway hypothesis of schizophrenia.NPJ schizophrenia · 2021Article
- Reply to: "Historical pursuits of the language pathway hypothesis of schizophrenia".NPJ schizophrenia · 2021Article
- Baseline Cortical Thickness Reductions in Clinical High Risk for Psychosis: Brain Regions Associated with Conversion to Psychosis Versus Non-Conversion as Assessed at One-Year Follow-Up in the Shanghai-At-Risk-for-Psychosis (SHARP) Study.Schizophrenia bulletin · 2021Article
- Altered resting-state functional connectivity in young children at familial high risk for psychotic illness: A preliminary study.Schizophrenia research · 2020Article
- Brain functional connectivity data enhance prediction of clinical outcome in youth at risk for psychosis.NeuroImage. Clinical · 2020Article
- Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study.NeuroImage. Clinical · 2017Article
- Electroconvulsive therapy-induced brain functional connectivity predicts therapeutic efficacy in patients with schizophrenia: a multivariate pattern recognition study.NPJ schizophrenia · 2017Article
- An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Neurophysiological differences between patients clinically at high risk for schizophrenia and neurotypical controls--first steps in development of a biomarker.BMC medicine · 2015Article
- A Hierarchical Generative Framework of Language Processing: Linking Language Perception, Interpretation, and Production Abnormalities in Schizophrenia.Frontiers in human neuroscience · 2015Review
- The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia.Schizophrenia research · 2014Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAbnormalities in language and language neural circuitry are observed in schizophrenia (SZ). Similar, but less pronounced language deficits are also seen in young first-degree relatives of people with SZ, who are at higher familial risk (FHR) for the disorder than the general population. The neural underpinnings of these deficits in people with FHR are unclear.
methodsParticipants were 43 people with FHR and 32 comparable controls. fMRI scans were collected while participants viewed associated and unrelated word pairs, and performed a lexical decision task. fMRI analyses conducted in SPM8 examined group differences in the modulation of hemodynamic activity by semantic association.
resultsThere were no group differences in demographics, IQ or behavioral semantic priming, but FHR participants had more schizotypal traits than controls. Controls exhibited the expected suppression of hemodynamic activity to associated versus unrelated word pairs. Compared to controls, FHR participants showed an opposite pattern of hemodynamic modulation to associated versus unrelated word pairs, in the left inferior frontal gyrus (IFG), right superior and middle temporal gyrus (STG) and the left cerebellum. Group differences in activation were significant, FWE-corrected for multiple comparisons (p<0.05). Activity within the IFG during the unrelated condition predicted schizotypal symptoms in FHR participants.
conclusionsFHR for SZ is associated with abnormally increased neural activity to semantic associates within an inferior frontal/temporal network. This might increase the risk of developing unusual ideas, perceptions and disorganized language that characterize schizotypal traits, potentially predicting which individuals are at greater risk to develop a psychotic disorder.
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