SynthesisAmerican heart journal2013
Posttraumatic stress disorder and risk for coronary heart disease: a meta-analytic review.
Synthesis in American heart journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03279393 (Stress and Atherosclerotic Plaque Macrophages), which is not on this map. Cited by 179 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress and Atherosclerotic Plaque Macrophages: A Systems Biology Approach - PET/MRI of the Brain-hematopoiesis-atherosclerosis Axis in PTSD Patients
Who cites it
179 citing papers in PubMed, 10 syntheses or guidelines pooled it, 358 citations in OpenAlex.
- Individual Participant Data Meta-Analysis Identifies Risk Factors for Acute and Persistent Posttraumatic Stress Disorder and Depression Symptoms Following Trauma.Depression and anxiety · 2026Pooled it
- Safety and efficacy of methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in post-traumatic stress disorder: An overview of systematic reviews and meta-analyses.The Australian and New Zealand journal of psychiatry · 2025Pooled it
- Lifetime posttraumatic stress disorder as a predictor of mortality: a systematic review and meta-analysis.BMC psychiatry · 2023Pooled it
- Associations between posttraumatic stress and stroke: A systematic review and meta-analysis.Journal of traumatic stress · 2023Pooled it
- Inflammatory and oxidative stress markers in post-traumatic stress disorder: a systematic review and meta-analysis.Molecular psychiatry · 2022Pooled it
- Posttraumatic Stress Disorder Treatment Effects on Cardiovascular Physiology: A Systematic Review and Agenda for Future Research.Journal of traumatic stress · 2021Pooled it
- The Diagnosis of Chronic Coronary Heart Disease.Deutsches Arzteblatt international · 2017Pooled it
- Guideline
- Violence and cardiovascular health: a systematic review.American journal of preventive medicine · 2015Pooled it
- Obstructive sleep apnea and psychiatric disorders: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Pooled it
- Community-Based Evaluation of the Associations Between Well-Being and Cardiovascular Disease Risk.Journal of the American Heart Association · 2022Trial
- Autism, Obesity, and PTSD Among Adolescents and Young Adults: An Analysis of National Medicaid Claims Data.Journal of autism and developmental disorders · 2026Article
- Prior Sexual Violence, PTSD Symptoms, and Recovery Trajectories After New Trauma.JAMA psychiatry · 2026Article
- Reply to "Veteran status as an underappreciated confound in narcolepsy mortality".Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Treating Psychological Factors in Patients With Heart Disease: Where Have We Been, How Shall We Proceed?Journal of the American Heart Association · 2026Article
- Polygenic risk factors for comorbid diagnoses in individuals with substance use disorders: A phenome-wide survival analysis.Psychological medicine · 2026Article
- State of the Science: The epidemiology of posttraumatic stress disorder.Journal of traumatic stress · 2026Review
- A brain-health framework for PTSD: integrating digital biomarkers into multimodal assessment.NPJ digital medicine · 2026Review
- Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets.iScience · 2026Review
- Post-Traumatic Stress Disorder After Acute Cardiovascular Events: Protocol of a Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Article
119 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe aim of this study was to estimate the association of posttraumatic stress disorder (PTSD) with risk for incident coronary heart disease (CHD).
designA systematic review and meta-analysis were used as study designs. DATA SOURCES: Articles were identified by searching Ovid MEDLINE, PsycINFO, Scopus, Cochrane Library, PILOTS database, and PubMed Related Articles and through a manual search of reference lists (1948-present). STUDY SELECTION: All studies that assessed PTSD in participants initially free of CHD and subsequently assessed CHD/cardiac-specific mortality were included. DATA EXTRACTION: Two investigators independently extracted estimates of the association of PTSD with CHD, as well as study characteristics. Odds ratios were converted to hazard ratios (HRs), and a random-effects model was used to pool results. A secondary analysis including only studies that reported estimates adjusted for depression was conducted.
resultsSix studies met our inclusion criteria (N = 402,274); 5 of these included depression as a covariate. The pooled HR for the magnitude of the relationship between PTSD and CHD was 1.55 (95% CI 1.34-1.79) before adjustment for depression. The pooled HR estimate for the 5 depression-adjusted estimates (N = 362,950) was 1.27 (95% CI 1.08-1.49).
conclusionPosttraumatic stress disorder is independently associated with increased risk for incident CHD, even after adjusting for depression and other covariates. It is common in both military veterans and civilian trauma survivors, and these results suggest that it may be a modifiable risk factor for CHD. Future research should identify the mechanisms of this association and determine whether PTSD treatment offsets CHD risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.