ArticleBioMed research international2013
Skeletal muscle regeneration on protein-grafted and microchannel-patterned scaffold for hypopharyngeal tissue engineering.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Porous biomaterial scaffolds for skeletal muscle tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Graft alignment impacts the regenerative response of skeletal muscle after volumetric muscle loss in a rat model.Acta biomaterialia · 2020Article
- Cold atmospheric plasma as a promising approach for gelatin immobilization on poly(ε-caprolactone) electrospun scaffolds.Progress in biomaterials · 2019Article
- Regulation of skeletal myotube formation and alignment by nanotopographically controlled cell-secreted extracellular matrix.Journal of biomedical materials research. Part A · 2018Article
- Silk fibroin scaffolds with muscle-like elasticity support in vitro differentiation of human skeletal muscle cells.Journal of tissue engineering and regenerative medicine · 2017Article
- Naturally derived and synthetic scaffolds for skeletal muscle reconstruction.Advanced drug delivery reviews · 2015Review
- Synthesis and Properties of Flexible Polyurethane Using Ferric Catalyst for Hypopharyngeal Tissue Engineering.BioMed research international · 2015Article
- Synthesis and characterization of biodegradable polyurethane for hypopharyngeal tissue engineering.BioMed research international · 2015Article
- Engineered hypopharynx from coculture of epithelial cells and fibroblasts using poly(ester urethane) as substratum.BioMed research international · 2013Article
- Advanced strategies for constructing interfacial tissues of bone and tendon/ligament.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the field of tissue engineering, polymeric materials with high biocompatibility like polylactic acid and polyglycolic acid have been widely used for fabricating living constructs. For hypopharynx tissue engineering, skeletal muscle is one important functional part of the whole organ, which assembles the unidirectionally aligned myotubes. In this study, a polyurethane (PU) scaffold with microchannel patterns was used to provide aligning guidance for the seeded human myoblasts. Due to the low hydrophilicity of PU, the scaffold was grafted with silk fibroin (PU-SF) or gelatin (PU-Gel) to improve its cell adhesion properties. Scaffolds were observed to degrade slowly over time, and their mechanical properties and hydrophilicities were improved through the surface grafting. Also, the myoblasts seeded on PU-SF had the higher proliferative rate and better differentiation compared with those on the control or PU-Gel. Our results demonstrate that polyurethane scaffolds seeded with myoblasts hold promise to guide hypopharynx muscle regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.