ArticleWorld journal of nephrology2013
Pericytes synthesize renin.
Article in World journal of nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Biology of vascular mural cells.Development (Cambridge, England) · 2023Review
- Renin Cells, From Vascular Development to Blood Pressure Sensing.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Renin Cells, the Kidney, and Hypertension.Circulation research · 2021Review
- Deciphering the Identity of Renin Cells in Health and Disease.Trends in molecular medicine · 2021Review
- Identification and characterization of cellular heterogeneity within the developing renal interstitium.Development (Cambridge, England) · 2020Article
- Sox6 as a new modulator of renin expression in the kidney.American journal of physiology. Renal physiology · 2020Article
- Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity.Oncotarget · 2018Review
- Pericytes in the renal vasculature: roles in health and disease.Nature reviews. Nephrology · 2018Review
- Renin cells in homeostasis, regeneration and immune defence mechanisms.Nature reviews. Nephrology · 2018Review
- Endocrine functions of the renal interstitium.Pflugers Archiv : European journal of physiology · 2017Review
- Fate of Renin Cells During Development and Disease.Hypertension (Dallas, Tex. : 1979) · 2017Review
- Tracking the stochastic fate of cells of the renin lineage after podocyte depletion using multicolor reporters and intravital imaging.PloS one · 2017Article
- Ototoxic effects and mechanisms of loop diuretics.Journal of otology · 2016Review
- Cells of renin lineage express hypoxia inducible factor 2α following experimental ureteral obstruction.BMC nephrology · 2016Article
- Novel Functions of Renin Precursors in Homeostasis and Disease.Physiology (Bethesda, Md.) · 2016Review
- Vascular versus tubular renin: role in kidney development.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium.American journal of physiology. Renal physiology · 2015Article
- Cells of renin lineage are adult pluripotent progenitors in experimental glomerular disease.American journal of physiology. Renal physiology · 2015Article
- Article
- Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4.Hypertension (Dallas, Tex. : 1979) · 2015Article
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Authors and funding
5 authors.
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Abstract
aimTo investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.
methodsWe examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type (WT) and angiotensinogen deficient (AGT -/-) mice at different developmental stages from embryonic day 18 (E18: WT, n = 4; AGT -/-, n = 5) and at day 1 (P1: WT, n = 5; AGT -/-, n = 5), 5 (P5: WT, n = 7; AGT -/-, n = 8), 10 (P10: WT, n = 3; AGT -/-, n = 5), 21 (P21: WT, n = 7; AGT -/-, n = 5), 45 (P45: WT, n = 3; AGT -/-, n = 3), and 70 (P70: WT, n = 2; AGT -/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and compared the results of AGT -/- mice to their WT counterparts.
resultsIn WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm(2) (density) in WT mice was maintained from fetal life till weaning age (E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life (P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT -/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63 (P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48 (P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48 (P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70 (P = 5.24567 × 10(-7)), P21 = 83 ± 6.70 vs 3.8 ± 0.58 (P = 2.97358 × 10(-6)), P45 = 49 ± 3.50 vs 1.2 ± 0.37 (P = 8.18274 x 10(-7)) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20 (P = 3.51151 × 10(-5)). The AGT -/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70.
conclusionInterstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen.
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