ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2013
Intelligence quotient in children with congenital hypothyroidism: The effect of diagnostic and treatment variables.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Congenital hypothyroidism and associated visual-motor and intellectual development.Pediatric research · 2025Article
- Hypothyroidism Among College Students and Its Association With Academic Performance: A Cross-Sectional Study.Cureus · 2023Article
- Neuropsychological Alterations in Patients with Congenital Hypothyroidism Treated with Levothyroxine: Linked Factors and Thyroid Hormone Hyposensitivity.Journal of clinical medicine · 2022Review
- Prevalence and predictive factors of transient and permanent congenital hypothyroidism in Fars province, Iran.BMC pediatrics · 2021Article
- Evaluation of the developmental outcome in children with congenital hypothyroidism.Caspian journal of internal medicine · 2021Article
- Developmental Screening of Children with Congenital Hypothyroidism Using Ages and Stages Questionnaires Test.Iranian journal of child neurology · 2019Article
- Estimation of Mean Intelligence Quotient with Wechsler Scale in Iran: Systematic Review and Meta-Analysis.International journal of preventive medicine · 2019Review
- Delayed Diagnosis of Hypothyroidism in Children: Report of 3 Cases.Iranian Red Crescent medical journal · 2015Article
- Prevalence of permanent congenital hypothyroidism in isfahan-iran.International journal of preventive medicine · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundConsidering the high prevalence of congenital hypothyroidism (CH) in Isfahan, the intelligence quotient (IQ) of children with CH and the effect of diagnostic and treatment variables on it were investigated during the CH screening program. MATERIALS AND
methodsA total of 120 children in three studied groups were studied in this comparative study the IQ score, in three subsets of verbal IQ, performance IQ and full scale IQ, of children diagnosed with transient congenital hypothyroidism (TCH) and permanent congenital hypothyroidism (PCH) was measured using revised Wechsler pre-school and primary scale of intelligence and compared with the control group. The relation between IQ score with time of treatment initiation and screening thyroid stimulating hormone (TSH) level was evaluated in all studied groups.
resultsMean of verbal IQ, performance IQ, and full scale IQ score was significantly higher in the control group than CH patients (both permanent and transient) In PCH patients though it was not significant, there was a negative relationship between verbal IQ, performance IQ and full scale IQ and screening TSH and age of treatment initiation. In TCH patients, there was negative and significant relationship between verbal IQ (r = -0.40) and full scale IQ (r = -0.38) and age of treatment initiation (r = -0.46).
conclusionMean IQ score in both PCH and TCH patients were lower than the control group, which correlates negatively with treatment initiation time. Though CH screening and early treatment has improved the prognosis of patients, but early and high dose of treatment in children with CH is recommended.
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24174944PMC3810573W1508368159What OpenQuestion holds
Registered trials
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