ArticleDementia and geriatric cognitive disorders extra2013
Correlates of Subjective and Mild Cognitive Impairment: Depressive Symptoms and CSF Biomarkers.
Article in Dementia and geriatric cognitive disorders extra, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Subjective Cognitive Impairment and Affective Symptoms: A Systematic Review.The Gerontologist · 2016Pooled it
- Subjective Cognitive Complaints and Objective Cognitive Function in Aging: A Systematic Review and Meta-Analysis of Recent Cross-Sectional Findings.Neuropsychology review · 2016Pooled it
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Loneliness and biomarkers of brain pathology in people with subjective cognitive decline.Scientific reports · 2025Article
- Associations of depressive symptoms and cortisol with cognitive performance among memory clinic patients.International psychogeriatrics · 2025Observational
- Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease.International journal of aging & human development · 2025Article
- Biomarkers of Alzheimer's Disease and Cerebrovascular Disease in Relation to Depressive Symptomatology in Individuals With Subjective Cognitive Decline.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Identifying and distinguishing cognitive profiles among virally suppressed people with HIV.Neuropsychology · 2024Article
- Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Metacognition, cortical thickness, and tauopathy in aging.Neurobiology of aging · 2022Article
- Distinct Profile Differences in Subjective Cognitive Decline in the General Public Are Associated with Metacognition, Negative Affective Symptoms, Neuroticism, Stress, and Poor Quality of Life.Journal of Alzheimer's disease : JAD · 2021Article
- Subjective and Objective Mental and Physical Functions Affect Subjective Cognitive Decline in Community-Dwelling Elderly Japanese People.Healthcare (Basel, Switzerland) · 2020Article
- Depression and APOEε4 Status in Individuals with Subjective Cognitive Decline: A Meta-Analysis.Psychiatry investigation · 2020Article
- Biomarker-Based Signature of Alzheimer's Disease in Pre-MCI Individuals.Brain sciences · 2019Review
- Subjective Cognitive Impairment in 55-65-Year-Old Adults Is Associated with Negative Affective Symptoms, Neuroticism, and Poor Quality of Life.Journal of Alzheimer's disease : JAD · 2019Article
- Asymmetry of Hippocampus and Amygdala Defect in Subjective Cognitive Decline Among the Community Dwelling Chinese.Frontiers in psychiatry · 2018Article
- Subjective Cognitive Decline and Alzheimer's Disease Spectrum Disorder.Dementia and neurocognitive disorders · 2017Review
- Help-Seeking among Male Employees in Japan: Influence of Workplace Climate and Distress.Journal of occupational health · 2016Article
- A Conceptualization of the Utility of Subjective Cognitive Decline in Clinical Trials of Preclinical Alzheimer's Disease.Journal of molecular neuroscience : MN · 2016Review
- The Relieving Effects of BrainPower Advanced, a Dietary Supplement, in Older Adults with Subjective Memory Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo improve early diagnosis of dementia disease, this study investigates correlates of cognitive complaints and cognitive test performance in patients with subjective (SCI) and mild (MCI) cognitive impairment.
methodsSeventy patients from a memory clinic, aged 45-79, with a score of 2 (n = 23) or 3 (n = 47) on the Global Deterioration Scale, were included. CSF biomarkers [Aβ42, total tau (T-tau) and phosphorylated tau (P-tau)], depressive symptoms, cognitive performance, and complaints were examined.
resultsCorrelation analysis showed that cognitive complaints increased with decreasing cognitive performance in SCI and decreased with decreasing performance in MCI. Linear regression models revealed that cognitive complaints were associated with depressive symptoms in both groups of patients, while cognitive performance was associated with CSF Aβ42 and P-tau in SCI and with T-tau and P-tau in MCI.
conclusionThese results suggest that depressive symptoms are associated with cognitive complaints, while degenerative changes are associated with objective cognitive decline in high-risk predementia states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.