Evidence map›Paper›PMID 24174903›Full record

ReviewDialogues in clinical neuroscience2013

Molecular imaging as a guide for the treatment of central nervous system disorders.

Euitae Kim, Oliver D Howes, Shitij Kapur

Open access · diamondAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Dialogues in clinical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Insight into the Molecular Imaging of Alzheimer's Disease.International journal of biomedical imaging · 2016
    Review
  11. Review
  12. Glutamate and dopamine in schizophrenia: an update for the 21st century.Journal of psychopharmacology (Oxford, England) · 2015
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Euitae KimDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggi-do 463-707, Korea.
Oliver D Howes
Shitij Kapur
Imperial College London · GBKing's College London · GBSeoul National University Bundang Hospital · KR

Funding

Medical Research Council G0700995Medical Research Council G0701748Medical Research Council MC_U120097115
6 · The paper itself

Abstract

Molecular imaging techniques have a number of advantages for research into the pathophysiology and treatment of central nervous system (CNS) disorders. Firstly, they provide a noninvasive means of characterizing physiological processes in the living brain, enabling molecular alterations to be linked to clinical changes. Secondly, the pathophysiological target in a given CNS disorder can be measured in animal models and in experimental human models in the same way, which enables translational research. Moreover, as molecular imaging facilitates the detection of functional change which precedes gross pathology, it is particularly useful for the early diagnosis and treatment of CNS disorders. This review considers the application of molecular imaging to CNS disorders focusing on its potential to inform the development and evaluation of treatments. We focus on schizophrenia, Parkinson's disease, depression, and dementia as major CNS disorders. We also review the potential of molecular imaging to guide new drug development for CNS disorders.

Indexed as

Practice Guidelines as TopicAnimalsBrainCentral Nervous System DiseasesHumansMolecular ImagingTreatment Outcomedepressionmolecular imagingParkinson's disease, dementiapositron emission tomographyschizophreniasingle photon emission computed tomography

Identifiers

PMID24174903
PMCPMC3811103
OpenAlexW2128216771

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.