Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
State-dependent effects of transcranial oscillatory currents on the motor system: what you think matters.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05085210 (Visual Restoration of Losses Caused by Cortical Damage), which is not on this map. Cited by 93 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Visual Restoration of Losses Caused by Cortical Damage: a New Protocol to Promote Fast Recovery
Who cites it
93 citing papers in PubMed, 5 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- Is transcranial alternating current stimulation effective for improving working memory? A three-level meta-analysis.Psychonomic bulletin & review · 2025Pooled it
- Efficacy of Transcranial Alternating Current Stimulation in the Enhancement of Working Memory Performance in Healthy Adults: A Systematic Meta-Analysis.Neuromodulation : journal of the International Neuromodulation Society · 2023Pooled it
- Effects of transcranial alternating current stimulation on motor performance and motor learning for healthy individuals: A systematic review and meta-analysis.Frontiers in physiology · 2022Pooled it
- Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Guideline
- Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis.Neurobiology of aging · 2015Pooled it
- Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation.Journal of neuroengineering and rehabilitation · 2025Trial
- Repetitive temporal interference stimulation improves jump performance but not the postural stability in young healthy males: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2024Trial
- No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations.Scientific reports · 2021Trial
- Intermittent tACS during a visual task impacts neural oscillations and LZW complexity.Experimental brain research · 2020Trial
- Efficacy of tRNS and 140 Hz tACS on motor cortex excitability seemingly dependent on sensitivity to sham stimulation.Experimental brain research · 2019Trial
- The effects of transcranial alternating current stimulation (tACS) at individual alpha peak frequency (iAPF) on motor cortex excitability in young and elderly adults.Experimental brain research · 2018Trial
- An Intrinsic Role of Beta Oscillations in Memory for Time Estimation.Scientific reports · 2018Trial
- Article
- Neural mechanisms underlying the after-effects of repetitive paired-pulse TMS with Β tACS on the human primary motor cortex.Scientific reports · 2025Article
- μ-Transcranial Alternating Current Stimulation Induces Phasic Entrainment and Plastic Facilitation of Corticospinal Excitability.The European journal of neuroscience · 2025Article
- Transcranial alternating current stimulation can modulate the blink reflex excitability. Effects of a 10- and 20-Hz tACS session on the blink reflex recovery cycle in healthy subjects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Utilizing tACS to enhance memory confidence and EEG to predict individual differences in brain stimulation efficacy.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- What can neurofeedback and transcranial alternating current stimulation reveal about cross-frequency coupling?Frontiers in neuroscience · 2025Article
- Neuroplastic effects of transcranial alternating current stimulation (tACS): from mechanisms to clinical trials.Frontiers in human neuroscience · 2025Review
- Individualized connectomic tACS immediately improves oscillatory network with language facilitation in post-stroke aphasia: a feasibility study of a dysfunctome-based targeting approach.Frontiers in computational neuroscience · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imperceptible transcranial alternating current stimulation (tACS) changes the endogenous cortical oscillatory activity in a frequency-specific manner. In the human motor system, tACS coincident with the idling beta rhythm of the quiescent motor cortex increased the corticospinal output. We reasoned that changing the initial state of the brain (i.e., from quiescence to a motor imagery task that desynchronizes the local beta rhythm) might also change the susceptibility of the corticospinal system to resonance effects induced by beta-tACS. We tested this hypothesis by delivering tACS at different frequencies (theta, alpha, beta, and gamma) on the primary motor cortex at rest and during motor imagery. Motor-evoked potentials (MEPs) were obtained by transcranial magnetic stimulation (TMS) on the primary motor cortex with an online-navigated TMS-tACS setting. During motor imagery, the increase of corticospinal excitability was maximal with theta-tACS, likely reflecting a reinforcement of working memory processes required to mentally process and "execute" the cognitive task. As expected, the maximal MEPs increase with subjects at rest was instead obtained with beta-tACS, substantiating previous evidence. This dissociation provides new evidence of state and frequency dependency of tACS effects on the motor system and helps discern the functional role of different oscillatory frequencies of this brain region. These findings may be relevant for rehabilitative neuromodulatory interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.