ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- TheeLife · 2026Article
- Review
- Identification and Profiling of MicroRNAs During Embryogenesis in the Red Claw CrayfishFrontiers in physiology · 2020Article
- The Conserved IgSF9 Protein Borderless Regulates Axonal Transport of Presynaptic Components and Color Vision inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Immunoglobulin-Like Receptors and Their Impact on Wiring of Brain Synapses.Annual review of genetics · 2018Review
- Turtle interacts with borderless in regulating glial extension and axon ensheathment.Molecular brain · 2017Article
- Transcriptomic analysis of instinctive and learned reward-related behaviors in honey bees.The Journal of experimental biology · 2016Article
- Control of axon-axon attraction by Semaphorin reverse signaling.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Establishment of synaptic connections in the neuropils of the developing nervous system requires the coordination of specific neurite-neurite interactions (i.e., axon-axon, dendrite-dendrite and axon-dendrite interactions). The molecular mechanisms underlying coordination of neurite-neurite interactions for circuit assembly are incompletely understood. In this report, we identify a novel Ig superfamily transmembrane protein that we named Borderless (Bdl), as a novel regulator of neurite-neurite interactions in Drosophila. Bdl induces homotypic cell-cell adhesion in vitro and mediates neurite-neurite interactions in the developing visual system. Bdl interacts physically and genetically with the Ig transmembrane protein Turtle, a key regulator of axonal tiling. Our results also show that the receptor tyrosine phosphatase leukocyte common antigen-related protein (LAR) negatively regulates Bdl to control synaptic-layer selection. We propose that precise regulation of Bdl action coordinates neurite-neurite interactions for circuit formation in Drosophila.
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Registered trials
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