ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 69 citations in OpenAlex.
- Advances in calcium signalling research for the diagnosis and treatment of depression.Annals of medicine · 2026Review
- Gender-Associated Differences in the Regulation of Potassium Channels in Astrocytes of Type 2 Diabetic Mice.Cells · 2026Article
- Astrocyte modulation of synaptic plasticity mediated by activity-dependent Sonic hedgehog signaling.bioRxiv : the preprint server for biology · 2024Article
- Altered synaptic currents, mitophagy, mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai capsules intervention.Journal of pharmaceutical analysis · 2024Article
- Astrocytic GPCR-Induced CaInternational journal of molecular sciences · 2023Article
- Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice.Nature communications · 2023Article
- Acute administration of ketone beta-hydroxybutyrate downregulates 7T proton magnetic resonance spectroscopy-derived levels of anterior and posterior cingulate GABA and glutamate in healthy adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Effect of Ouabain on Glutamate Transport in the Hippocampus of Rats with LPS-Induced Neuroinflammation.Biomedicines · 2023Article
- Calcium signaling in astrocytes and gliotransmitter release.Frontiers in synaptic neuroscience · 2023Review
- Editorial: Natural products and brain energy metabolism: Astrocytes in neurodegenerative diseases Volume II.Frontiers in pharmacology · 2023Article
- Glymphatic Dysfunction Induced Oxidative Stress and Neuro-Inflammation in Major Depression Disorders.Antioxidants (Basel, Switzerland) · 2022Review
- Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Editorial: Natural products and brain energy metabolism: Astrocytes in neurodegenerative diseases.Frontiers in pharmacology · 2022Article
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Astrocytic modulation of potassium under seizures.Neural regeneration research · 2020Review
- The Paradox of Astroglial CaFrontiers in cellular neuroscience · 2020Review
- Piperine Attenuates TBI-Induced Seizures via Inhibiting Cytokine-Activated Reactive Astrogliosis.Frontiers in neurology · 2020Article
- Generating Brain Waves, the Power of Astrocytes.Frontiers in neuroscience · 2019Review
- Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks.Journal of neurophysiology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Astrocytes in hippocampal slices can dynamically regulate synaptic transmission in a process mediated by increases in intracellular Ca(2+). However, it is debated whether astrocytic Ca(2+) signals result in release of glutamate. We here compared astrocytic Ca(2+) signaling triggered by agonist exposure versus photolysis side by side. Using transgenic mice in which astrocytes selectively express the MrgA1 receptor, we found that receptor-mediated astrocytic Ca(2+) signaling consistently triggered neuronal hyperpolarization and decreased the frequency of miniature excitatory postsynaptic currents (EPSCs). In contrast, photolysis of caged Ca(2+) (o-nitrophenyl-EGTA) in astrocytes led to neuronal depolarization and increased the frequency of mEPSCs through a metabotropic glutamate receptor-mediated pathway. Analysis of transgenic mice in which astrocytic vesicular release is suppressed (dominant-negative SNARE mice) and pharmacological manipulations suggested that glutamate is primarily released by opening of anion channels rather than exocytosis. Combined, these studies show that photolysis but not by agonists induced astrocytic Ca(2+) signaling triggers glutamate release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.