ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Spontaneous and evoked release are independently regulated at individual active zones.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
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Who cites it
133 citing papers in PubMed, 217 citations in OpenAlex.
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- Impact of distinct neurotransmitter release modes on neuronal signaling.Molecular psychiatry · 2026Review
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- Functional Nano-segregation of Distinct Forms of Neurotransmission.Advances in neurobiology · 2026Review
- Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics.Advances in neurobiology · 2026Review
- Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Synaptobrevin-2 disease variants reveal spatial constraints within the presynaptic active zone.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Activity-Dependent Increases in Quantal Size at theJournal of developmental biology · 2025Article
- Presynaptic quantal size enhancement counteracts post-tetanic release depression.The Journal of physiology · 2025Article
- MiR-92 Controls Synaptic Development Through Glial Vha55 Regulation.Biomolecules · 2025Article
- Trans-synaptic molecular context of NMDA receptor nanodomains.Nature communications · 2025Article
- Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Balanced synapse-to-synapse short-term plasticity ensures constant transmitter release.Current biology : CB · 2025Article
- Building and modifying diverse synaptic properties: Insights from Drosophila.Current opinion in neurobiology · 2025Review
- Functionally distinct evoked and spontaneous neurotransmission operate via a shared pool of synaptic vesicles in viscerosensory afferents.The Journal of physiology · 2025Article
- Distinct transmission sites within a synapse for strengthening and homeostasis.Science advances · 2025Article
- The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses.PLoS biology · 2025Article
- Type-specific molecular signaling architectures and synaptic plasticity ofFrontiers in cellular neuroscience · 2025Article
- High frequency stimulation activates hot spots of spontaneous synaptic transmission.Frontiers in synaptic neuroscience · 2025Article
- Functional specificity of liquid-liquid phase separation at the synapse.Nature communications · 2024Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neurotransmitter release from synaptic vesicle fusion is the fundamental mechanism for neuronal communication at synapses. Evoked release following an action potential has been well characterized for its function in activating the postsynaptic cell, but the significance of spontaneous release is less clear. Using transgenic tools to image single synaptic vesicle fusion events at individual release sites (active zones) in Drosophila, we characterized the spatial and temporal dynamics of exocytotic events that occur spontaneously or in response to an action potential. We also analyzed the relationship between these two modes of fusion at single release sites. A majority of active zones participate in both modes of fusion, although release probability is not correlated between the two modes of release and is highly variable across the population. A subset of active zones is specifically dedicated to spontaneous release, indicating a population of postsynaptic receptors is uniquely activated by this mode of vesicle fusion. Imaging synaptic transmission at individual release sites also revealed general rules for spontaneous and evoked release, and indicate that active zones with similar release probability can cluster spatially within individual synaptic boutons. These findings suggest neuronal connections contain two information channels that can be spatially segregated and independently regulated to transmit evoked or spontaneous fusion signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.