ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Olfactory wiring logic in amphibians challenges the basic assumptions of the unbranched axon concept.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- When noncanonical olfaction is optimal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Functional odor map heterogeneity is based on multifaceted glomerular connectivity in larvaliScience · 2023Article
- Axon terminals control endolysosome diffusion to support synaptic remodelling.Life science alliance · 2021Article
- Resolving different presynaptic activity patterns within single olfactory glomeruli of Xenopus laevis larvae.Scientific reports · 2021Article
- Olfaction across the water-air interface in anuran amphibians.Cell and tissue research · 2021Review
- Multi-glomerular projection of single olfactory receptor neurons is conserved among amphibians.The Journal of comparative neurology · 2020Article
- Subpopulations of Projection Neurons in the Olfactory Bulb.Frontiers in neural circuits · 2020Review
- Conservation of Glomerular Organization in the Main Olfactory Bulb of Anuran Larvae.Frontiers in neuroanatomy · 2020Article
- From neurogenesis to neuronal regeneration: the amphibian olfactory system as a model to visualize neuronal development in vivo.Neural regeneration research · 2015Article
- Dual processing of sulfated steroids in the olfactory system of an anuran amphibian.Frontiers in cellular neuroscience · 2015Article
- The olfactory system as a model to study axonal growth patterns and morphology in vivo.Journal of visualized experiments : JoVE · 2014Article
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Authors and funding
2 authors.
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Abstract
Olfactory receptor neurons extend axons into the olfactory bulb, where they face the challenge to integrate into existing circuitry. The consensus view is that in vertebrates individual receptor neurons project unbranched axons into one specific glomerulus of the olfactory bulb. We report here that, strikingly different from the generally assumed wiring principle in vertebrate olfactory systems, axons of single receptor neurons of Xenopus laevis regularly bifurcate and project into more than one glomerulus. Specifically, the innervation of multiple glomeruli is present in all ontogenetic stages of this species, from the larva to the postmetamorphic frog. Also, we show that this unexpected wiring pattern is not restricted to axons of immature receptor neurons, but that it is also a feature of mature neurons of both the main and accessory olfactory system. This glomerular innervation pattern is unique among vertebrates investigated so far and represents a new olfactory wiring strategy.
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