Evidence map›Paper›PMID 24174657›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013

Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage.

Linnea R Vose, Govindaiah Vinukonda, Sungro Jo, Omid Miry, Daniel Diamond, Ritesh Korumilli, Arslan Arshad, Muhammad T K Zia, Furong Hu, Robert J Kayton and 4 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
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  5. Article
  6. SECISBP2L-Mediated Selenoprotein Synthesis Is Essential for Autonomous Regulation of Oligodendrocyte Differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  7. Recovery of the brain after intraventricular hemorrhage.Seminars in fetal & neonatal medicine · 2022
    Review
  8. Review
  9. PPAR-γ activation enhances myelination and neurological recovery in premature rabbits with intraventricular hemorrhage.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Linnea R VoseDepartments of Pediatrics, and Cell Biology and Anatomy, Regional Neonatal Center, Maria Fareri Children's Hospital at Westchester Medical Center-New York Medical College, Valhalla, New York 10595, Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, Department of Neuroscience, University of Connecticut, Farmington, Connecticut 06269, and Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33146.
Govindaiah Vinukonda
Sungro Jo
Omid Miry
Daniel Diamond
Ritesh Korumilli
Arslan Arshad
Muhammad T K Zia
Furong Hu
Robert J Kayton
Edmund F La Gamma
Rashmi Bansal
Antonio C Bianco
Praveen Ballabh
Pediatrics and Genetics · USMaria Fareri Children's Hospital · USUniversity of Miami · USNew York Medical College · USOregon Health & Science University · USUniversity of Connecticut · USWestchester Medical Center · US

Funding

Metabolic and Xenobiotic Control of Thyroid Hormone MetabolismR01DK077148 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ANTONIO C BIANCO · 2007 to 2026
$4.5M
White matter injury in germinal matrix hemorrhageR01NS071263 · NINDS · NEW YORK MEDICAL COLLEGE · PI BALLABH, PRAVEEN · 2010 to 2013
$1.4M
NIDDK NIH HHS R01 DK077148NINDS NIH HHS R01 NS071263
6 · The paper itself

Abstract

Intraventricular hemorrhage (IVH) remains a major cause of white matter injury in preterm infants with no viable therapeutic strategy to restore myelination. Maturation of oligodendrocytes and myelination is influenced by thyroid hormone (TH) signaling, which is mediated by TH receptor α (TRα) and TRβ. In the brain, cellular levels of TH are regulated by deiodinases, with deiodinase-2 mediating TH activation and deiodinase-3 TH inactivation. Therefore, we hypothesized that IVH would decrease TH signaling via changes in the expression of deiodinases and/or TRs, and normalization of TH signaling would enhance maturation of oligodendrocytes and myelination in preterm infants with IVH. These hypotheses were tested using both autopsy materials from human preterm infants and a rabbit model of IVH. We found that deiodinase-2 levels were reduced, whereas deiodinase-3 levels were increased in brain samples of both humans and rabbits with IVH compared with controls without IVH. TRα expression was also increased in human infants with IVH. Importantly, treatment with TH accelerated the proliferation and maturation of oligodendrocytes, increased transcription of Olig2 and Sox10 genes, augmented myelination, and restored neurological function in pups with IVH. Consistent with these findings, the density of myelinating oligodendrocytes was almost doubled in TH-treated human preterm infants compared with controls. Thus, in infants with IVH the combined elevation in deiodinase-3 and reduction in deiodinase-2 decreases TH signaling that can be worsened by an increase in unliganded TRα. Given that TH promotes neurological recovery in IVH, TH treatment might improve the neurodevelopmental outcome of preterm infants with IVH.

Indexed as

AnimalsAnimals, NewbornCerebral HemorrhageCerebral VentriclesDisease Models, AnimalDouble-Blind MethodFemaleHumansInfant, NewbornInfant, PrematureMaleMyelin SheathRabbitsRecovery of FunctionThyroxineTreatment OutcomeThyroxine

Identifiers

PMID24174657
PMCPMC3812500
OpenAlexW1992073888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.