ArticleJournal of neurophysiology2014
Abnormal functional connectivity between motor cortex and pedunculopontine nucleus following chronic dopamine depletion.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- Article
- Tractography patterns of pedunculopontine nucleus deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Article
- Roles of Motor Cortex Neuron Classes in Reach-Related Modulation for Hemiparkinsonian Rats.Frontiers in neuroscience · 2021Article
- Response to "Concerns regarding Baksa et al., Cell Molec. Life Sci., 2019." by Edgar Garcia-Rill and Francisco J. Urbano (CMLS-D-18-0156R1).Cellular and molecular life sciences : CMLS · 2019Article
- Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.Frontiers in neurology · 2018Article
- Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals.Frontiers in neurology · 2018Article
- Granger causality supports abnormal functional connectivity of beta oscillations in the dorsolateral striatum and substantia nigra pars reticulata in hemiparkinsonian rats.Experimental brain research · 2017Article
- Functional Connectivity of the Pedunculopontine Nucleus and Surrounding Region in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Astrocyte-Dependent Slow Inward Currents (SICs) Participate in Neuromodulatory Mechanisms in the Pedunculopontine Nucleus (PPN).Frontiers in cellular neuroscience · 2017Article
- Near-infrared light (670 nm) reduces MPTP-induced parkinsonism within a broad therapeutic time window.Experimental brain research · 2016Article
- Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms.Frontiers in neural circuits · 2015Article
- Oscillations in pedunculopontine nucleus in Parkinson's disease and its relationship with deep brain stimulation.Frontiers in neural circuits · 2015Review
- Oscillatory Activity in Basal Ganglia and Motor Cortex in an Awake Behaving Rodent Model of Parkinson's Disease.Basal ganglia · 2014Article
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Authors and funding
5 authors.
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Abstract
The activity of the basal ganglia is altered in Parkinson's disease (PD) as a consequence of the degeneration of dopamine neurons in the substantia nigra pars compacta. This results in aberrant discharge patterns and expression of exaggerated oscillatory activity across the basal ganglia circuit. Altered activity has also been reported in some of the targets of the basal ganglia, including the pedunculopontine nucleus (PPN), possibly due to its close interconnectivity with most regions of the basal ganglia. However, the nature of the involvement of the PPN in the pathophysiology of PD has not been fully elucidated. Here, we recorded local field potentials in the motor cortex and the PPN in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of PD under urethane anesthesia. By means of linear and nonlinear statistics, we analyzed the synchrony between the motor cortex and the PPN and the delay in the interaction between these two structures. We observed the presence of coherent activity between the cortex and the PPN in low (5-15 Hz)- and high (25-35 Hz)-frequency bands during episodes of cortical activation. In each case, the cortex led the PPN. Dopamine depletion strengthened the interaction of the low-frequency activities by increasing the coherence specifically in the theta and alpha ranges and reduced the delay of the interaction in the gamma band. Our data show that cortical inputs play a determinant role in leading the coherent activity with the PPN and support the involvement of the PPN in the pathophysiology of PD.
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