ArticleBMJ (Clinical research ed.)2013
The relation between total joint arthroplasty and risk for serious cardiovascular events in patients with moderate-severe osteoarthritis: propensity score matched landmark analysis.
Article in BMJ (Clinical research ed.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Time for return to sport following total knee arthroplasty: a meta-analysis.Archives of orthopaedic and trauma surgery · 2022Pooled it
- Examining Timeliness of Total Knee Replacement Among Patients with Knee Osteoarthritis in the U.S.: Results from the OAI and MOST Longitudinal Cohorts.The Journal of bone and joint surgery. American volume · 2020Pooled it
- Return to Sports and Physical Activity After Total and Unicondylar Knee Arthroplasty: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2016Pooled it
- Cerebrovascular disease and postoperative cognitive-related complications after knee arthroplasty: evidence from a nationwide cohort.Knee surgery & related research · 2026Article
- Association between sustained opioid use and survival or major adverse cardiovascular events after total knee arthroplasty: evidence from a population-based cohort.BMC anesthesiology · 2026Article
- The impact of total joint arthroplasty on arterial stiffness in osteoarthritis patients: a 7-year prospective cohort study (CAMERA study).Scientific reports · 2025Article
- Perioperative Outcomes of Simultaneous Bilateral Total Knee Arthroplasty in Elderly Indian Patients: A Retrospective Study.Journal of orthopaedic case reports · 2025Article
- Shared Mechanisms Between Osteoarthritis and Cardiovascular Disease: A Clinical and Pathophysiological Review.Cureus · 2025Review
- Head-to-head comparison of appropriate use criteria for knee arthroplasty: A multicenter cohort study.Osteoarthritis and cartilage open · 2024Article
- An interpretable knee replacement risk assessment system for osteoarthritis patients.Osteoarthritis and cartilage open · 2024Article
- The Long-Term View-Assessing Life Expectancy Post-Knee Arthroplasty: A Commentary on "Life Expectancy of Patients Undergoing Total Knee Arthroplasty: Comparison With General Population".Journal of Korean medical science · 2024Article
- Life Expectancy of Patients Undergoing Total Knee Arthroplasty: Comparison With General Population.Journal of Korean medical science · 2024Article
- Article
- Effect of repeat catheter ablation vs. antiarrhythmic drug therapy among patients with recurrent atrial tachycardia/atrial fibrillation after atrial fibrillation catheter ablation: data from CHINA-AF registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- The Regional Burden and Disability-Adjusted Life Years of Knee Osteoarthritis in Kazakhstan 2014-2020.Biomedicines · 2023Article
- Effect of sodium bicarbonate on cardiovascular outcome and mortality in patients with advanced chronic kidney disease.Frontiers in pharmacology · 2023Article
- Prediction models for the risk of total knee replacement: development and validation using data from multicentre cohort studies.The Lancet. Rheumatology · 2022Article
- Predictors of Co-occurring Cardiovascular and Gastrointestinal Disorders among Elderly with Osteoarthritis.Osteoarthritis and cartilage open · 2021Article
- How Does Mortality Risk Change Over Time After Hip and Knee Arthroplasty?Clinical orthopaedics and related research · 2019Article
- Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference.The Journal of the American Academy of Orthopaedic Surgeons · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine whether total joint arthroplasty of the hip and knee reduces the risk for serious cardiovascular events in patients with moderate-severe osteoarthritis.
designPropensity score matched landmark analysis.
settingOntario, Canada.
participants2200 adults with hip or knee osteoarthritis aged 55 or more at recruitment (1996-98) and followed prospectively until death or 2011.
main outcome measureRates of serious cardiovascular events for those who received a primary total joint arthroplasty compared with those did not within an exposure period of three years after baseline assessment.
resultsThe propensity score matched cohort consisted of 153 matched pairs of participants with moderate-severe arthritis. Over a median follow-up period of seven years after the landmark date (start of the study), matched participants who underwent a total joint arthroplasty during the exposure period were significantly less likely than those who did not to experience a cardiovascular event (hazards ratio 0.56, 95% confidence interval 0.43 to 0.74, P<0.001). Within seven years of the exposure period the absolute risk reduction was 12.4% (95% confidence interval 1.7% to 23.1%) and number needed to treat was 8 (95% confidence interval 4 to 57 patients).
conclusionsUsing a propensity matched landmark analysis in a population cohort with advanced hip or knee osteoarthritis, this study found a cardioprotective benefit of primary elective total joint arthroplasty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.