Trial reportNeurology2013
Total cerebral blood flow and mortality in old age: a 12-year follow-up study.
Trial report in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Transcranial doppler assessment of preoperative cerebral blood flow velocity in cardiac surgery patients.Journal of clinical monitoring and computing · 2026Observational
- Cerebral Hemodynamics as a Diagnostic Bridge Between Mild Cognitive Impairment and Late-Life Depression: A Multimodal Approach Using Transcranial Doppler and MRI.Life (Basel, Switzerland) · 2025Article
- Article
- Imputation models and error analysis for phase contrast MR cerebral blood flow measurements in heterogeneous pediatric and adult populations.Frontiers in physiology · 2025Article
- Automated Quantification of Total Cerebral Blood Flow from Phase-Contrast MRI and Deep Learning.Journal of imaging informatics in medicine · 2024Article
- Early-Frame [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Imputation models and error analysis for phase contrast MR cerebral blood flow measurements.Frontiers in physiology · 2023Article
- Reduced parenchymal cerebral blood flow is associated with greater progression of brain atrophy: The SMART-MR study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Contributions of Cerebral Blood Flow to Associations Between Blood Pressure Levels and Cognition: The Age, Gene/Environment Susceptibility-Reykjavik Study.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Vertebral artery hypoplasia influences age-related differences in blood flow of the large intracranial arteries.Aging brain · 2021Article
- Article
- Comparison of global cerebral blood flow measured by phase-contrast mapping MRI withJournal of magnetic resonance imaging : JMRI · 2017Article
- Article
- Kidney Function and Cerebral Blood Flow: The Rotterdam Study.Journal of the American Society of Nephrology : JASN · 2016Article
- Blood flow distribution in cerebral arteries.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo examine the association of total cerebral blood flow (CBF) with all-cause, noncardiovascular, and cardiovascular mortality in older subjects at risk of cardiovascular disease.
methodsWe included 411 subjects with a mean age of 74.5 years from the MRI substudy of the Prospective Study of Pravastatin in the Elderly at Risk. Total CBF was measured at baseline, and occurrence of death was recorded in an average follow-up period of 11.8 years. For each participant, total CBF was standardized for brain parenchymal volume. Cox regression models were used to estimate risk of all-cause, noncardiovascular, and cardiovascular mortality in relation to CBF.
resultsMortality rates among participants in low, middle, and high thirds of total CBF were 52.1, 41.5, and 28.7 per 1,000 person-years, respectively. Compared with participants in the high third of CBF, participants in the low third had 1.88-fold (95% confidence interval [CI]: 1.30-2.72) higher risk of all-cause mortality, 1.66-fold (95% CI: 1.06-2.59) higher risk of noncardiovascular mortality, and 2.50-fold (95% CI: 1.28-4.91) higher risk of cardiovascular mortality. Likewise, compared with participants in the high third of CBF, participants in the middle third had 1.44-fold (95% CI: 0.98-2.11) higher risk of all-cause mortality, 1.29-fold (95% CI: 0.82-2.04) higher risk of noncardiovascular mortality, and 1.86-fold (95% CI: 0.93-3.74) higher risk of cardiovascular mortality. These associations were independent of prevalent vascular status and risk factors.
conclusionsLow total CBF is linked with higher risk of all-cause, noncardiovascular, and cardiovascular mortality in older people independent of clinical cardiovascular status.
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