ArticleNeurology2013
Temporal trends in new exposure to antiepileptic drug monotherapy and suicide-related behavior.
Article in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Epilepsy, excess deaths and years of life lost from external causes.European journal of epidemiology · 2016Pooled it
- An exploratory study evaluating the 20 medications most commonly associated with suicidal ideation and self-injurious behavior in the FAERS database.BMC pharmacology & toxicology · 2025Article
- Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy: An Analysis of a Complex Comorbidity.Neurology · 2023Article
- Suicide and Epilepsy.Current neurology and neuroscience reports · 2022Review
- Suicidality in Patients With Epilepsy: Why Should Neurologists Care?Frontiers in integrative neuroscience · 2022Review
- Editorial: Psychiatric Comorbidities in the Epilepsies: Extensive Mechanisms and Broad Questions.Frontiers in integrative neuroscience · 2022Article
- A pharmacovigilance approach for assessing the occurrence of suicide-related events induced by antiepileptic drugs using the Japanese adverse drug event report database.Frontiers in psychiatry · 2022Article
- Antiepileptic Drugs and Suicidality in Veterans with Seizures.Neurology (E-Cronicon) · 2019Article
- Antiepileptic drugs and suicide-related behavior: Is it the drug or comorbidity?Neurology. Clinical practice · 2018Review
- Providing Quality Epilepsy Care for Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2016Article
- Hospital care for mental health and substance abuse in children with epilepsy.Epilepsy & behavior : E&B · 2016Article
- Anxiety and epilepsy: what neurologists and epileptologists should know.Current neurology and neuroscience reports · 2014Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveBecause some recent studies suggest increased risk for suicide-related behavior (SRB; ideation, attempts) among those receiving antiepileptic drugs (AEDs), we examined the temporal relationship between new AED exposure and SRB in a cohort of older veterans.
methodsWe used national Veterans Health Administration databases to identify veterans aged ≥65 years who received a new AED prescription in 2004-2006. All instances of SRB were identified using ICD-9-CM codes 1 year before and after the AED exposure (index) date. We also identified comorbid conditions and medication associated with SRB in prior research. We used generalized estimating equations with a logit link to examine the association between new AED exposure and SRB during 30-day intervals during the year before and after the index date, controlling for potential confounders.
resultsIn this cohort of 90,263 older veterans, the likelihood of SRB the month prior to AED exposure was significantly higher than in other time periods even after adjusting for potential confounders. Although there were 87 SRB events (74 individuals) the year before and 106 SRB events (92 individuals) after, approximately 22% (n = 16) of those also had SRB before the index date. Moreover, the rate of SRB after AED start was gradually reduced over time.
conclusionsThe temporal pattern of AED exposure and SRB suggests that, in clinical practice, the peak in SRB is prior to exposure. While speculative, the rate of gradual reduction in SRB thereafter suggests that symptoms may prompt AED prescription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.