ArticleJournal of computational neuroscience2014
Open loop optogenetic control of simulated cortical epileptiform activity.
Article in Journal of computational neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures.International journal of molecular sciences · 2022Article
- Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2017Article
- Suppression of epileptic seizures via Anderson localization.Journal of the Royal Society, Interface · 2017Article
- A probabilistic method for determining cortical dynamics during seizures.Journal of computational neuroscience · 2015Article
- Future of seizure prediction and intervention: closing the loop.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015Review
- Beyond the hammer and the scalpel: selective circuit control for the epilepsies.Nature neuroscience · 2015Article
- Optimal control based seizure abatement using patient derived connectivity.Frontiers in neuroscience · 2015Article
- Optogenetic induced epileptiform activity in a model human cortex.SpringerPlus · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a model for the use of open loop optogenetic control to inhibit epileptiform activity in a meso scale model of the human cortex. The meso scale cortical model first developed by Liley et al. (2001) is extended to two dimensions and the nature of the seizure waves is studied. We adapt to the meso scale a 4 state functional model of Channelrhodopsin-2 (ChR2) ion channels. The effects of pulsed and constant illumination on the conductance of these ion channels is presented. The inhibitory cell population is targeted for the application of open loop control. Seizure waves are successfully suppressed and the inherent properties of the optogenetic channels ensures charge balance in the cortex, protecting it from damage.
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Registered trials
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