ArticleChembiochem : a European journal of chemical biology2013
Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.
Article in Chembiochem : a European journal of chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Targeted metabolism creates possibilities for lung cancer treatment in the precision tumor era.Respiratory research · 2026Review
- Lactate metabolism and lactylation in breast cancer: mechanisms and implications.Cancer metastasis reviews · 2025Review
- Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells.Nature metabolism · 2025Article
- Biomimetic Approach to Promote Cellular Uptake and Enhance Photoacoustic Properties of Tumor-Seeking Dyes.Journal of the American Chemical Society · 2023Article
- Targeting Energy Metabolism in Cancer Treatment.International journal of molecular sciences · 2022Review
- Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction.Oncoscience · 2020Article
- Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds.British journal of cancer · 2020Article
- Article
- Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents.Molecules (Basel, Switzerland) · 2019Article
- Extrinsic and Intrinsic Immunometabolism Converge: Perspectives on Future Research and Therapeutic Development for Obesity.Current obesity reports · 2019Review
- Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NADCell metabolism · 2019Article
- Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.Molecules (Basel, Switzerland) · 2017Review
- Brucella abortus Induces a Warburg Shift in Host Metabolism That Is Linked to Enhanced Intracellular Survival of the Pathogen.Journal of bacteriology · 2017Article
- Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death.ACS chemical biology · 2017Article
- d- Versus l-Glucose Conjugation: Mitochondrial Targeting of a Light-Activated Dual-Mode-of-Action Ruthenium-Based Anticancer Prodrug.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Anticancer agents interacting with membrane glucose transporters.MedChemComm · 2016Article
- Recent Advances in Biosensing With Photonic Crystal Surfaces: A Review.IEEE sensors journal · 2016Article
- Emerging concepts of T cell metabolism as a target of immunotherapy.Nature immunology · 2016Article
- Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death.Scientific reports · 2015Article
- Development and validation of a docking-based virtual screening platform for the identification of new lactate dehydrogenase inhibitors.Molecules (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Effective glucose diet: We report the development and activity of glucose-conjugated LDH-A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.