ArticleProceedings. Biological sciences2013
Immune anticipation of mating in Drosophila: Turandot M promotes immunity against sexually transmitted fungal infections.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Viruses in LaboratoryViruses · 2023Article
- Individual variation in preference behavior in sailfin fish refines the neurotranscriptomic pathway for mate preference.Ecology and evolution · 2023Article
- Article
- Experimental sexual selection reveals rapid evolutionary divergence in sex-specific transcriptomes and their interactions following mating.Molecular ecology · 2022Article
- Article
- Fitness Analysis and Transcriptome Profiling Following Repeated Mild Heat Stress of Varying Frequency inBiology · 2021Article
- Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity.BMC biology · 2021Article
- Article
- Interactions with ectoparasitic mites induce host metabolic and immune responses in flies at the expense of reproduction-associated factors.Parasitology · 2020Article
- Microorganisms in the reproductive tissues of arthropods.Nature reviews. Microbiology · 2020Review
- Female bed bugs (Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Analysis of natural female post-mating responses of Anopheles gambiae and Anopheles coluzzii unravels similarities and differences in their reproductive ecology.Scientific reports · 2018Article
- Mating system manipulation and the evolution of sex-biased gene expression in Drosophila.Nature communications · 2017Article
- Roles of Female and Male Genotype in Post-Mating Responses in Drosophila melanogaster.The Journal of heredity · 2017Article
- Polyandry enhances offspring viability with survival costs to mothers only when mating exclusively with virgin males inEcology and evolution · 2017Article
- The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel.PLoS pathogens · 2017Article
- Regular Wounding in a Natural System: Bacteria Associated With Reproductive Organs of Bedbugs and Their Quorum Sensing Abilities.Frontiers in immunology · 2017Article
- Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury ineLife · 2016Article
- Cold-seeking behaviour mitigates reproductive losses from fungal infection in Drosophila.The Journal of animal ecology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Although it is well known that mating increases the risk of infection, we do not know how females mitigate the fitness costs of sexually transmitted infections (STIs). It has recently been shown that female fruitflies, Drosophila melanogaster, specifically upregulate two members of the Turandot family of immune and stress response genes, Turandot M and Turandot C (TotM and TotC), when they hear male courtship song. Here, we use the Gal4/UAS RNAi gene knockdown system to test whether the expression of these genes provides fitness benefits for females infected with the entomopathogenic fungus, Metarhizium robertsii under sexual transmission. As a control, we also examined the immunity conferred by Dorsal-related immunity factor (Dif), a central component of the Toll signalling pathway thought to provide immunity against fungal infections. We show that TotM, but not TotC or Dif, provides survival benefits to females following STIs, but not after direct topical infections. We also show that though the expression of TotM provides fecundity benefits for healthy females, it comes at a cost to their survival, which helps to explain why TotM is not constitutively expressed. Together, these results show that the anticipatory expression of TotM promotes specific immunity against fungal STIs and suggest that immune anticipation is more common than currently appreciated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.