ArticleParasitology research2014
Inhibitory effect of allicin on the growth of Babesia and Theileria equi parasites.
Article in Parasitology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 74 citations in OpenAlex.
- Recent advancements in phytotherapeutics for controlling babesiosis and theileriosis.Tropical animal health and production · 2026Review
- Equine piroplasmosis: an emerging tick-borne threat to equine health.Tropical animal health and production · 2026Review
- The Safety and Efficacy of an Immunomodulator Garlic-Based Cream (LeishG1) for Treating Uncomplicated Cutaneous Leishmaniasis: A Single-Blind, Multi-Center Study.Health science reports · 2025Article
- Progress in serology and molecular biology of equine parasite diagnosis: sustainable control strategies.Frontiers in veterinary science · 2025Review
- The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses.Microorganisms · 2023Review
- Review
- Article
- Evaluation of the Inhibitory Effect ofJournal of tropical medicine · 2023Article
- Antiparasitic activity of FLLL-32 against fourFrontiers in pharmacology · 2023Article
- Repurposing of the Malaria Box for Babesia microti in mice identifies novel active scaffolds against piroplasmosis.Parasites & vectors · 2022Article
- Evaluation of theJournal of advanced veterinary and animal research · 2022Article
- Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment.Frontiers in pharmacology · 2022Review
- Pomegranate (Journal of parasitology research · 2022Article
- Effect of methanolic extract fromVeterinary world · 2022Article
- Identification of Essential Oils Including Garlic Oil and Black Pepper Oil with High Activity againstPathogens (Basel, Switzerland) · 2020Article
- Myrrh OilPathogens (Basel, Switzerland) · 2020Article
- Therapeutic Effects of Atranorin towards the Proliferation ofPathogens (Basel, Switzerland) · 2020Article
- Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.PloS one · 2020Article
- Screening the Medicines for Malaria Venture Pathogen Box against piroplasm parasites.International journal for parasitology. Drugs and drug resistance · 2019Article
- Flavonoids isolated from the flowers of Pulsatilla flavescens and their anti-piroplasm activity.Journal of natural medicines · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allicin is an active ingredient of garlic that has antibacterial, antifungal, antiviral, and antiprotozoal activity. However, the inhibitory effects of allicin on Babesia parasites have not yet been examined. In the present study, allicin was tested as a potent inhibitor against the in vitro growth of bovine and equine Babesia parasites and the in vivo growth of Babesia microti in a mouse model. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia caballi, or Theileria equi was inhibited by allicin in a dose-dependent manner and had IC50 values of 818, 675, 470, and 742 μM, respectively. Moreover, allicin significantly inhibited (P < 0.001) invasion of B. bovis, B. bigemina, B. caballi, and T. equi into the host erythrocyte. Furthermore, mice treated with 30 mg/kg of allicin for 5 days significantly (P < 0.05) reduced the parasitemia of B. microti over the period of the study. To further examine the potential synergism of allicin with diminazene aceturate, growth inhibitory assays were performed in vitro and in vivo. Interestingly, combinations of diminazene aceturate with allicin synergistically potentiated its inhibitory effects in vitro and in vivo. These results indicate that allicin might be beneficial for the treatment of babesiosis, particularly when used in combination with diminazene aceturate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.