ArticleMolecular biology of the cell2014
Autophagosomes contribute to intracellular lipid distribution in enterocytes.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Selective autophagy of intracellular organelles: recent research advances.Theranostics · 2021Pooled it
- Quantitative Lipid Analysis of Extracellular Vesicle Preparations: A Perspective.Journal of extracellular vesicles · 2025Article
- Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?Cold Spring Harbor perspectives in biology · 2023Review
- AmAtg2B-Mediated Lipophagy Regulates Lipolysis of Pupae inInternational journal of molecular sciences · 2023Article
- High-fat diet induces intestinal mucosal barrier dysfunction in ulcerative colitis: emerging mechanisms and dietary intervention perspective.American journal of translational research · 2023Review
- New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases.Frontiers in pharmacology · 2023Review
- Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy.Oxidative medicine and cellular longevity · 2023Article
- ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER-mitochondria contact sites.The Journal of cell biology · 2022Article
- When fat meets the gut-focus on intestinal lipid handling in metabolic health and disease.EMBO molecular medicine · 2022Review
- The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders.Cell death & disease · 2022Review
- Review
- The Molecular Brakes of Adipose Tissue Lipolysis.Frontiers in physiology · 2022Review
- Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish.eLife · 2021Article
- A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?Oxidative medicine and cellular longevity · 2021Review
- Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases.Molecular & cellular proteomics : MCP · 2020Article
- The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells.Nature cell biology · 2020Article
- Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance.Autophagy · 2020Article
- Reserve lipids and plant autophagy.Journal of experimental botany · 2020Review
- A Newly Identified LncRNA LncIMF4 Controls Adipogenesis of Porcine Intramuscular Preadipocyte through Attenuating Autophagy to Inhibit Lipolysis.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterocytes, the intestinal absorptive cells, have to deal with massive alimentary lipids upon food consumption. They orchestrate complex lipid-trafficking events that lead to the secretion of triglyceride-rich lipoproteins and/or the intracellular transient storage of lipids as lipid droplets (LDs). LDs originate from the endoplasmic reticulum (ER) membrane and are mainly composed of a triglyceride (TG) and cholesterol-ester core surrounded by a phospholipid and cholesterol monolayer and specific coat proteins. The pivotal role of LDs in cellular lipid homeostasis is clearly established, but processes regulating LD dynamics in enterocytes are poorly understood. Here we show that delivery of alimentary lipid micelles to polarized human enterocytes induces an immediate autophagic response, accompanied by phosphatidylinositol-3-phosphate appearance at the ER membrane. We observe a specific and rapid capture of newly synthesized LD at the ER membrane by nascent autophagosomal structures. By combining pharmacological and genetic approaches, we demonstrate that autophagy is a key player in TG targeting to lysosomes. Our results highlight the yet-unraveled role of autophagy in the regulation of TG distribution, trafficking, and turnover in human enterocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.