ArticleScientific reports2013
Optical control of neuronal excitation and inhibition using a single opsin protein, ChR2.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Retrograde optogenetics reveals sensorimotor convergence within a corticotectal pathway of non-human primates.Current biology : CB · 2026Article
- Retrograde Optogenetics Reveals Functional Convergence within a Corticotectal Pathway of Non-Human Primates.bioRxiv : the preprint server for biology · 2025Article
- Design, Fabrication, and Implantation of Invasive Microelectrode Arrays as in vivo Brain Machine Interfaces: A Comprehensive Review.Journal of manufacturing processes · 2024Article
- Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion.Nature methods · 2023Article
- mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Image-guided focused ultrasound modulates electrically evoked motor neuronal activity in the mouse peripheral nervous system in vivo.Journal of neural engineering · 2020Article
- Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review.Journal of neuroengineering and rehabilitation · 2020Review
- Insights Into Spinal Dorsal Horn Circuit Function and Dysfunction Using Optical Approaches.Frontiers in neural circuits · 2020Review
- A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles.Nature communications · 2019Article
- On the development of optical peripheral nerve interfaces.Neural regeneration research · 2019Review
- Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves.Scientific reports · 2018Article
- End-to-End Design of Efficient Ultrasonic Power Links for Scaling Towards Submillimeter Implantable Receivers.IEEE transactions on biomedical circuits and systems · 2018Article
- Anterior Cingulate Cortex Input to the Claustrum Is Required for Top-Down Action Control.Cell reports · 2018Article
- Optogenetic and chemogenetic strategies for sustained inhibition of pain.Scientific reports · 2016Article
- Optogenetic Interrogation of Functional Synapse Formation by Corticospinal Tract Axons in the Injured Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Evolution of Neuroprosthetic Interfaces.Critical reviews in biomedical engineering · 2016Review
- A neural coding scheme reproducing foraging trajectories.Scientific reports · 2015Article
- Illuminating neural circuits and behaviour in Caenorhabditis elegans with optogenetics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Escalated Aggression in Animal Models: Shedding New Light on Mesocorticolimbic Circuits.Current opinion in behavioral sciences · 2015Article
- Optical Stimulation of Neurons.Current molecular imaging · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The effect of electrical stimulation on neuronal membrane potential is frequency dependent. Low frequency electrical stimulation can evoke action potentials, whereas high frequency stimulation can inhibit action potential transmission. Optical stimulation of channelrhodopsin-2 (ChR2) expressed in neuronal membranes can also excite action potentials. However, it is unknown whether optical stimulation of ChR2-expressing neurons produces a transition from excitation to inhibition with increasing light pulse frequencies. Here we report optical inhibition of motor neuron and muscle activity in vivo in the cooled sciatic nerves of Thy1-ChR2-EYFP mice. We also demonstrate all-optical single-wavelength control of neuronal excitation and inhibition without co-expression of inhibitory and excitatory opsins. This all-optical system is free from stimulation-induced electrical artifacts and thus provides a new approach to investigate mechanisms of high frequency inhibition in neuronal circuits in vivo and in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.