ArticleEuropean archives of psychiatry and clinical neuroscience2014
Cluster analysis of cognitive deficits may mark heterogeneity in schizophrenia in terms of outcome and response to treatment.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Brain Morphological Characteristics of Cognitive Subgroups of Schizophrenia-Spectrum Disorders and Bipolar Disorder: A Systematic Review with Narrative Synthesis.Neuropsychology review · 2023Pooled it
- A Systematic Review of Studies Reporting Data-Driven Cognitive Subtypes across the Psychosis Spectrum.Neuropsychology review · 2020Pooled it
- A systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficits.Translational psychiatry · 2020Pooled it
- Heterogeneity of Treatment Effects of Long-Acting Injectable Antipsychotic Medications.The Journal of clinical psychiatry · 2018Trial
- Exploring the impact of cognitive profiles on the response to magnetic seizure therapy and electroconvulsive therapy.Molecular psychiatry · 2026Article
- Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Article
- Integrated clinical and postmortem profiling in schizophrenia reveals a cognitive subtype linked to cerebrovascular disease.Translational psychiatry · 2026Article
- Beyond severity: Mapping cognitive heterogeneity in schizophrenia at the structural level.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive and clinical profiles in first-episode psychosis and their relationship with functional outcomes.The British journal of psychiatry : the journal of mental science · 2026Article
- Do Cognitive Subtypes Exist in People at Clinical High Risk for Psychosis? Results From the EU-GEI Study.Schizophrenia bulletin · 2025Article
- Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study.Translational psychiatry · 2025Article
- Cognitive Correlates of Functional Disruption at Psychosis Onset: Unique Relevance of Visual Cognition.Journal of clinical medicine · 2025Article
- Exploring the latent cognitive structure in schizophrenia: implications for antipsychotic treatment responses.European archives of psychiatry and clinical neuroscience · 2025Article
- Why clinical neuropsychology matters in schizophrenia care.Frontiers in psychology · 2025Review
- Maternal Immune Activation Induces Adolescent Cognitive Deficits Preceded by Developmental Perturbations in Cortical Reelin Signalling.Biomolecules · 2023Article
- Deconstructing heterogeneity in schizophrenia through language: a semi-automated linguistic analysis and data-driven clustering approach.Schizophrenia (Heidelberg, Germany) · 2022Article
- Clustering of cognitive phenotypes identifies susceptible and resilient offspring in a rat model of maternal immune activation and early-life stress.Brain, behavior, & immunity - health · 2022Article
- Examining the association of life course neurocognitive ability with real-world functioning in schizophrenia-spectrum disorders.Schizophrenia research. Cognition · 2022Article
- Lifespan evolution of neurocognitive impairment in schizophrenia - A narrative review.Schizophrenia research. Cognition · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Cognitive impairments are central to schizophrenia, but their clinical utility for tagging heterogeneity in lifetime outcome and response to treatment is not conclusive. By exploiting four cognitive domains consistently showing large deficits in studies, we tested whether cluster analysis would define separate subsets of patients and then whether the disease heterogeneity marked by these clusters would be related to lifetime outcome and response to treatment. A total of 112 schizophrenia patients completed a neuropsychological evaluation. The PANSS, GAF-S and GAF-F were rated at the onset and endpoint of the illness trajectory. A blind judgment of the lifetime response to treatment was made. The first cluster presented near-normal cognitive performance. Two other clusters of severely impaired patients were identified: one generally impaired in the four cognitive domains and another selectively impaired in visual episodic memory and processing speed, each relating to a different lifetime evolution of disease and treatment response. Although the two impaired clusters were clinically indistinguishable in symptom severity and functioning at disease onset, patients with selective cognitive impairments demonstrated better improvement at outcome, whereas the generally impaired patients were more likely to be treatment refractory. The findings have implications for the management of patients and for clinical trials since particular combinations of cognitive deficits in patients would influence their treatment response.
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