ArticleProceedings of the National Academy of Sciences of the United States of America2013
Submillisecond second harmonic holographic imaging of biological specimens in three dimensions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Fourier synthesis optical diffraction tomography for kilohertz rate volumetric imaging.Science advances · 2025Article
- Statistical estimation theory detection limits for label-free imaging.Journal of biomedical optics · 2024Article
- Recent Advances and Current Trends in Transmission Tomographic Diffraction Microscopy.Sensors (Basel, Switzerland) · 2024Review
- Harmonic optical tomography of nonlinear structures.Nature photonics · 2020Article
- Demonstration of flat-top beam illumination in widefield multiphoton microscopy.Journal of biomedical optics · 2019Article
- Fluorescent coherent diffractive imaging with accelerating light sheets.Optics express · 2019Article
- Label-free and live cell imaging by interferometric scattering microscopy.Chemical science · 2018Article
- Application of an advanced maximum likelihood estimation restoration method for enhanced-resolution and contrast in second-harmonic generation microscopy.Journal of microscopy · 2017Article
- Superresolved multiphoton microscopy with spatial frequency-modulated imaging.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Collagen Fibrils in Skin Orient in the Direction of Applied Uniaxial Load in Proportion to Stress while Exhibiting Differential Strains around Hair Follicles.Materials (Basel, Switzerland) · 2015Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Optical microscopy has played a critical role for discovery in biomedical sciences since Hooke's introduction of the compound microscope. Recent years have witnessed explosive growth in optical microscopy tools and techniques. Information in microscopy is garnered through contrast mechanisms, usually absorption, scattering, or phase shifts introduced by spatial structure in the sample. The emergence of nonlinear optical contrast mechanisms reveals new information from biological specimens. However, the intensity dependence of nonlinear interactions leads to weak signals, preventing the observation of high-speed dynamics in the 3D context of biological samples. Here, we show that for second harmonic generation imaging, we can increase the 3D volume imaging speed from sub-Hertz speeds to rates in excess of 1,500 volumes imaged per second. This transformational capability is possible by exploiting coherent scattering of second harmonic light from an entire specimen volume, enabling new observational capabilities in biological systems.
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