ArticleScientific reports2013
TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Unique and shared patterns of chemosensory dysfunction distinguish chronic COVID-19 and aspirin-exacerbated respiratory disease.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026Review
- Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension?Particle and fibre toxicology · 2025Article
- Activation of the nucleus accumbens promotes place preference and counteracts stress-induced hyperthermia.iScience · 2024Article
- The physiological role of TRP channels in sleep and circadian rhythm.Journal of cellular and molecular medicine · 2024Review
- Article
- Linalool odor-induced analgesia is triggered by TRPA1-independent pathway in mice.Behavioral and brain functions : BBF · 2021Article
- Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels.Frontiers in endocrinology · 2021Review
- Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice.Frontiers in physiology · 2020Article
- Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.Nature communications · 2018Article
- Characterization of TRPA channels in the starfish Patiria pectinifera: involvement of thermally activated TRPA1 in thermotaxis in marine planktonic larvae.Scientific reports · 2017Article
- Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation.Frontiers in neuroscience · 2017Article
- Nasal TRPA1 mediates irritant-induced bradypnea in mice.Physiological reports · 2016Article
- Odour-induced analgesia mediated by hypothalamic orexin neurons in mice.Scientific reports · 2016Article
- Species-specific temperature sensitivity of TRPA1.Temperature (Austin, Tex.)Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detecting threats and escaping before serious confrontations are important for animals to avoid danger and death. Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily, is expressed in a subset of sensory neurons and mediates nociception evoked by pungent chemicals. Using behavioral testing, we found that TRPA1 knockout mice failed to avoid entering a chamber filled with vapor of formalin, allyl isothiocyanate, and acrolein. The avoidance behavior was blocked by nasal but not subcutaneous administration of a blocker to TRPA1. We also found that TRPA1 knockout mice did not wake when exposed to formalin during sleep. Additionally, the spinal trigeminal nucleus, the first relay neurons of the trigeminal system, showed massive expression of c-Fos after a brief (3 min) exposure to formalin vapor. TRPA1 seems to be a sentinel for environmental chemicals and induces avoidance behaviors and waking by way of the trigeminal system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.