ArticleThe Journal of experimental biology2013
Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges.
Article in The Journal of experimental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Arousal from hibernation increases blood oxygen saturation in 13-lined ground squirrels.The Journal of experimental biology · 2025Article
- Variations in HBA gene contribute to high-altitude hypoxia adaptation via affected OFrontiers in zoology · 2024Article
- Glutathione Non-Covalent Binding Sites on Hemoglobin and Major Glutathionylation Target betaCys93 Are Conservative among Both Hypoxia-Sensitive and Hypoxia-Tolerant Mammal Species.International journal of molecular sciences · 2023Article
- Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia.Molecular aspects of medicine · 2022Review
- Ecological correlates of the morphology of the auditory bulla in rodents: Application to the fossil record.Journal of anatomy · 2022Article
- Time Domains of Hypoxia Responses and -Omics Insights.Frontiers in physiology · 2022Review
- Effect of NH2-terminal acetylation on the oxygenation properties of vertebrate haemoglobin.The Biochemical journal · 2020Article
- Ontogenesis of evolved changes in respiratory physiology in deer mice native to high altitude.The Journal of experimental biology · 2020Article
- Structure and function of crocodilian hemoglobins and allosteric regulation by chloride, ATP, and COAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Oxygenation properties of hemoglobin and the evolutionary origins of isoform multiplicity in an amphibious air-breathing fish, the blue-spotted mudskipper (The Journal of experimental biology · 2020Article
- Evolution of physiological performance capacities and environmental adaptation: insights from high-elevation deer mice (Journal of mammalogy · 2019Article
- Compensatory mutations and epistasis for protein function.Current opinion in structural biology · 2018Review
- Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Migration-Selection Balance Drives Genetic Differentiation in Genes Associated with High-Altitude Function in the Speckled Teal (Anas flavirostris) in the Andes.Genome biology and evolution · 2018Article
- Regulation of blood oxygen transport in hibernating mammals.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin.Molecular biology and evolution · 2017Article
- Hemoglobin-oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?The Journal of experimental biology · 2016Review
- Bohr effect and temperature sensitivity of hemoglobins from highland and lowland deer mice.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2016Article
- Causes of molecular convergence and parallelism in protein evolution.Nature reviews. Genetics · 2016Review
- Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level.PLoS genetics · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Semi-fossorial ground squirrels face challenges to respiratory gas transport associated with the chronic hypoxia and hypercapnia of underground burrows, and such challenges are compounded in species that are native to high altitude. During hibernation, such species must also contend with vicissitudes of blood gas concentrations and plasma pH caused by episodic breathing. Here, we report an analysis of hemoglobin (Hb) function in six species of marmotine ground squirrels with different altitudinal distributions. Regardless of their native altitude, all species have high Hb-O2 affinities, mainly due to suppressed sensitivities to allosteric effectors [2,3-diphosphoglycerate (DPG) and chloride ions]. This suppressed anion sensitivity is surprising given that all canonical anion-binding sites are conserved. Two sciurid species, the golden-mantled and thirteen-lined ground squirrel, have Hb-O2 affinities that are characterized by high pH sensitivity and low thermal sensitivity relative to the Hbs of humans and other mammals. The pronounced Bohr effect is surprising in light of highly unusual amino acid substitutions at the C-termini that are known to abolish the Bohr effect in human HbA. Taken together, the high O2 affinity of sciurid Hbs suggests an enhanced capacity for pulmonary O2 loading under hypoxic and hypercapnic conditions, while the large Bohr effect should help to ensure efficient O2 unloading in tissue capillaries. In spite of the relatively low thermal sensitivities of the sciurid Hbs, our results indicate that the effect of hypothermia on Hb oxygenation is the main factor contributing to the increased blood-O2 affinity in hibernating ground squirrels.
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