ArticleMucosal immunology2014
Early-life exposure to combustion-derived particulate matter causes pulmonary immunosuppression.
Article in Mucosal immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 71 citations in OpenAlex.
- Pollutant particle priming amplifies airway compartment specific neutrophil and macrophage inflammatory programs following house dust mite acute exposure.Frontiers in immunology · 2026Article
- Multiomics profiles of genome-wide alterations in H3K27ac in different lung lobes after acute graft-Frontiers in immunology · 2025Article
- Inflammatory response in mouse lungs to haze episodes under different backgrounds of particulate matter exposure.Scientific reports · 2023Article
- Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice.Inhalation toxicology · 2023Article
- Microplastics: A Matter of the Heart (and Vascular System).Biomedicines · 2023Review
- Exposure duration of ambient fine particulate matter determines the polarization of macrophages.Central-European journal of immunology · 2023Article
- A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence.Particle and fibre toxicology · 2022Review
- Impact of biochar, fertilizers and cultivation type on environmentally persistent free radicals in agricultural soil.Environmental technology & innovation · 2022Article
- Exposure to Microplastics during Early Developmental Stage: Review of Current Evidence.Toxics · 2022Review
- Exposure to combustion derived particulate matter exacerbates influenza infection in neonatal mice by inhibiting IL22 production.Particle and fibre toxicology · 2021Article
- Association between particulate matter containing EPFRs and neutrophilic asthma through AhR and Th17.Respiratory research · 2021Article
- Air pollution and children's health-a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter.Environmental health and preventive medicine · 2021Review
- Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The interplay between environmental exposures and COVID-19 risks in the health of children.Environmental health : a global access science source · 2021Article
- Cumulative Effects of Particulate Matter Pollution and Meteorological Variables on the Risk of Influenza-Like Illness.Viruses · 2021Article
- Current pet ownership modifies the adverse association between long-term ambient air pollution exposure and childhood asthma.Clinical and translational allergy · 2021Article
- Mechanistic Implications of Biomass-Derived Particulate Matter for Immunity and Immune Disorders.Toxics · 2021Review
- The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective.Journal of immunology research · 2020Review
- In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization.Toxicology letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Elevated levels of combustion-derived particulate matter (CDPM) are a risk factor for the development of lung diseases such as asthma. Studies have shown that CDPM exacerbates asthma, inducing acute lung dysfunction and inflammation; however, the impact of CDPM exposure on early immunological responses to allergens remains unclear. To determine the effects of early-life CDPM exposure on allergic asthma development in infants, we exposed infant mice to CDPM and then induced a mouse model of asthma using house dust mite (HDM) allergen. Mice exposed to CDPM+HDM failed to develop a typical asthma phenotype including airway hyper-responsiveness, T-helper type 2 (Th2) inflammation, Muc5ac expression, eosinophilia, and HDM-specific immunoglobulin (Ig) compared with HDM-exposed mice. Although HDM-specific IgE was attenuated, total IgE was twofold higher in CDPM+HDM mice compared with HDM mice. We further demonstrate that CDPM exposure during early life induced an immunosuppressive environment in the lung, concurrent with increases in tolerogenic dendritic cells and regulatory T cells, resulting in the suppression of Th2 responses. Despite having early immunosuppression, these mice develop severe allergic inflammation when challenged with allergen as adults. These findings demonstrate a mechanism whereby CDPM exposure modulates adaptive immunity, inducing specific antigen tolerance while amplifying total IgE, and leading to a predisposition to develop asthma upon rechallenge later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.