SynthesisThe review of diabetic studies : RDS2013
Type 1 diabetes, diabetic nephropathy, and pregnancy: a systematic review and meta-study.
Synthesis in The review of diabetic studies : RDS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Autoimmune diseases and adverse pregnancy outcomes: an umbrella review.BMC medicine · 2024Pooled it
- Pregnancy in Glomerular Disease: From Risk Identification to Counseling and Management.Journal of clinical medicine · 2024Review
- Intrauterine Growth Restriction Due to Gestational Diabetes: From Pathophysiology to Diagnosis and Management.Medicina (Kaunas, Lithuania) · 2023Review
- Management of type 2 diabetes in pregnancy: a narrative review.Frontiers in endocrinology · 2023Review
- Two pregnancies after simultaneous pancreas-kidney transplantation: A case report.Obstetric medicine · 2020Article
- Pregnancy in Chronic Kidney Disease: Need for Higher Awareness. A Pragmatic Review Focused on What Could Be Improved in the Different CKD Stages and Phases.Journal of clinical medicine · 2018Review
- Reproductive health and pregnancy in women with chronic kidney disease.Nature reviews. Nephrology · 2018Review
- 21st century obstetrics: a 50-year-old nullip-walk in the park?BMJ case reports · 2018Article
- Review
- A best practice position statement on pregnancy in chronic kidney disease: the Italian Study Group on Kidney and Pregnancy.Journal of nephrology · 2016Review
- Diagnosis and Management of IUGR in Pregnancy Complicated by Type 1 Diabetes Mellitus.Current diabetes reports · 2016Review
- Diabetic Nephropathy in Women With Preexisting Diabetes: From Pregnancy Planning to Breastfeeding.Current diabetes reports · 2016Review
- Managing pregnancy in chronic kidney disease: improving outcomes for mother and baby.International journal of women's health · 2016Review
- Risk of Adverse Pregnancy Outcomes in Women with CKD.Journal of the American Society of Nephrology : JASN · 2015Observational
- Vascular complications in the diabetic pregnancy.Current diabetes reports · 2015Review
- Diabetic Kidney Disease: A Syndrome Rather Than a Single Disease.The review of diabetic studies : RDSReview
- Maternal and fetal outcomes of pregnancy in chronic kidney disease: diagnostic challenges, surveillance and treatment throughout the spectrum of kidney disease.Jornal brasileiro de nefrologiaArticle
- Piper betel leaves induces wound healing activity via proliferation of fibroblasts and reducing 11β hydroxysteriod dehydrogenase-1 expression in diabetic rat.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the last decade, significant improvements have been achieved in maternal-fetal and diabetic care which make pregnancy possible in an increasing number of type 1 diabetic women with end-organ damage. Optimal counseling is important to make the advancements available to the relevant patients and to ensure the safety of mother and child. A systematic review will help to provide a survey of the available methods and to promote optimal counseling.
objectivesTo review the literature on diabetic nephropathy and pregnancy in type 1 diabetes.
methodsMedline, Embase, and the Cochrane Library were scanned in November 2012 (MESH, Emtree, and free terms on pregnancy and diabetic nephropathy). Studies were selected that report on pregnancy outcomes in type 1 diabetic patients with diabetic nephropathy in 1980-2012 (i.e. since the detection of microalbuminuria). Case reports with less than 5 cases and reports on kidney grafts were excluded. Paper selection and data extraction were performed in duplicate and matched for consistency. As the relevant reports were highly heterogeneous, we decided to perform a narrative review, with discussions oriented towards the period of publication.
resultsOf the 1058 references considered, 34 fulfilled the selection criteria, and one was added from reference lists. The number of cases considered in the reports, which generally involved single-center studies, ranged from 5 to 311. The following issues were significant: (i) the evidence is scattered over many reports of differing format and involving small series (only 2 included over 100 patients), (ii) definitions are non-homogeneous, (iii) risks for pregnancy-related adverse events are increased (preterm delivery, caesarean section, perinatal death, and stillbirth) and do not substantially change over time, except for stillbirth (from over 10% to about 5%), (iv) the increase in risks with nephropathy progression needs confirmation in large homogeneous series, (v) the newly reported increase in malformations in diabetic nephropathy underlines the need for further studies.
conclusionsThe heterogeneous evidence from studies on diabetic nephropathy in pregnancy emphasizes the need for further perspective studies on this issue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.