ArticleKidney international2014
Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation.
Article in Kidney international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- EBF1 Regulates Cardiac Development Through Fibroblast to Myocyte Signaling.Journal of cardiovascular development and disease · 2026Article
- Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy.Scientific reports · 2025Article
- CpG methylation changes associated with hyperglycemia in type 1 diabetes occur at angiogenic glomerular and retinal gene loci.Scientific reports · 2025Article
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- Article
- Early B-cell transcription factor-2 defect as a novel cause of lipodystrophy: disruption of the adipose tissue character and integrity.medRxiv : the preprint server for health sciences · 2024Article
- The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation.Development (Cambridge, England) · 2023Article
- Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues.NPJ Regenerative medicine · 2022Review
- Review
- Decoding the Mechanism behind the Pathogenesis of the Focal Segmental Glomerulosclerosis.Computational and mathematical methods in medicine · 2022Article
- Review
- EBF1 is expressed in pericytes and contributes to pericyte cell commitment.Histochemistry and cell biology · 2021Article
- Promoter hypermethylation of early B cell factor 1 (EBF1) is associated with cholangiocarcinoma progression.Journal of Cancer · 2021Article
- IL-1β Drives Production of FGF-23 at the Onset of Chronic Kidney Disease in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Transcription Factor EBF1 Over-Expression Suppresses Tumor GrowthFrontiers in oncology · 2020Article
- Mesangial Cells: The Tuft Guys of Glomerular Development.Journal of the American Society of Nephrology : JASN · 2019Article
- Early B Cell Factor 1 (EBF1) Regulates Glomerular Development by Controlling Mesangial Maturation and Consequently COX-2 Expression.Journal of the American Society of Nephrology : JASN · 2019Article
- Human Organ-Specific Endothelial Cell Heterogeneity.iScience · 2018Article
- Prolonged oxidative stress down-regulates Early B cell factor 1 with inhibition of its tumor suppressive function against cholangiocarcinoma genesis.Redox biology · 2018Article
- Epigenome-wide association studies identify DNA methylation associated with kidney function.Nature communications · 2017Article
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Abstract
The coordination of multiple cytokines and transcription factors with their downstream signaling pathways has been shown to be integral to nephron maturation. Here we present a completely novel role for the helix-loop-helix transcription factor Early B-cell factor 1 (Ebf1), originally identified for B-cell maturation, for the proper maturation of glomerular cells from mesenchymal progenitors. The expression of Ebf1 was both spatially and temporally regulated within the developing cortex and glomeruli. Using Ebf1-null mice, we then identified biochemical, metabolic, and histological abnormalities in renal development that arose in the absence of this transcription factor. In the Ebf1 knockout mice, the developed kidneys show thinned cortices and reduced glomerular maturation. The glomeruli showed abnormal vascularization and severely effaced podocytes. The mice exhibited early albuminuria and elevated blood urea nitrogen levels. Moreover, the glomerular filtration rate was reduced >66% and the expression of podocyte-derived vascular endothelial growth factor A was decreased compared with wild-type control mice. Thus, Ebf1 has a significant and novel role in glomerular development, podocyte maturation, and the maintenance of kidney integrity and function.
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