Trial reportCritical care (London, England)2013
Short-term effects of noisy pressure support ventilation in patients with acute hypoxemic respiratory failure.
Trial report in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00786292 (Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury (EVA-Trial)
Who cites it
16 citing papers in PubMed.
- Variable pressure support ventilation vs. biphasic positive airway pressure/airway pressure release ventilation in experimental acute respiratory failure.BMC anesthesiology · 2026Article
- Comparisons of respiratory mechanics in patients under different variations of noisy pressure support ventilation during ventilator weaning.Journal of thoracic disease · 2025Article
- Heterogeneous impact of Sighs on mortality in patients with acute hypoxemic respiratory failure: insights from the PROTECTION study.Annals of intensive care · 2024Article
- Automated characterization of patient-ventilator interaction using surface electromyography.Annals of intensive care · 2024Article
- Decreased breathing variability is associated with poorer outcome in mechanically ventilated patients.ERJ open research · 2023Article
- Effects of Different Levels of Variability and Pressure Support Ventilation on Lung Function in Patients With Mild-Moderate Acute Respiratory Distress Syndrome.Frontiers in physiology · 2021Article
- Patient-ventilator asynchronies during mechanical ventilation: current knowledge and research priorities.Intensive care medicine experimental · 2019Review
- The Effects of Positive End-Expiratory Pressure on Transpulmonary Pressure and Recruitment-Derecruitment During Neurally Adjusted Ventilator Assist: A Continuous Computed Tomography Study in an Animal Model of Acute Respiratory Distress Syndrome.Frontiers in physiology · 2019Article
- Multicenter study on the prognosis associated with respiratory support for children with acute hypoxic respiratory failure.Experimental and therapeutic medicine · 2016Article
- Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet.American journal of respiratory and critical care medicine · 2016Article
- Variable ventilation from bench to bedside.Critical care (London, England) · 2016Review
- Approaches to ventilation in intensive care.Deutsches Arzteblatt international · 2014Review
- Year in review 2013: Critical Care--respirology.Critical care (London, England) · 2014Review
- Low tidal volume pressure support versus controlled ventilation in early experimental sepsis in pigs.Respiratory research · 2014Article
- Should we breathe quiet or noisy?Critical care (London, England) · 2014Article
- Variable mechanical ventilation.Revista Brasileira de terapia intensivaReview
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aims at comparing the very short-term effects of conventional and noisy (variable) pressure support ventilation (PSV) in mechanically ventilated patients with acute hypoxemic respiratory failure.
methodsThirteen mechanically ventilated patients with acute hypoxemic respiratory failure were enrolled in this monocentric, randomized crossover study. Patients were mechanically ventilated with conventional and noisy PSV, for one hour each, in random sequence. Pressure support was titrated to reach tidal volumes approximately 8 mL/kg in both modes. The level of positive end-expiratory pressure and fraction of inspired oxygen were kept unchanged in both modes. The coefficient of variation of pressure support during noisy PSV was set at 30%. Gas exchange, hemodynamics, lung functional parameters, distribution of ventilation by electrical impedance tomography, breathing patterns and patient-ventilator synchrony were analyzed.
resultsNoisy PSV was not associated with any adverse event, and was well tolerated by all patients. Gas exchange, hemodynamics, respiratory mechanics and spatial distribution of ventilation did not differ significantly between conventional and noisy PSV. Noisy PSV increased the variability of tidal volume (24.4 ± 7.8% vs. 13.7 ± 9.1%, P <0.05) and was associated with a reduced number of asynchrony events compared to conventional PSV (5 (0 to 15)/30 min vs. 10 (1 to 37)/30 min, P <0.05).
conclusionsIn the very short term, noisy PSV proved safe and feasible in patients with acute hypoxemic respiratory failure. Compared to conventional PSV, noisy PSV increased the variability of tidal volumes, and was associated with improved patient-ventilator synchrony, at comparable levels of gas exchange.
trial registrationClinicialTrials.gov, NCT00786292.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.