ReviewMolecules (Basel, Switzerland)2013
Effect of pressure on thermal stability of g-quadruplex DNA and double-stranded DNA structures.
Review in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Exploration of Carotenoid-Producing Microorganisms from the Kuril-Kamchatka Trench and Their Antioxidant Potential.Marine drugs · 2026Article
- Investigation of long-term pressure on primary packaging materials and a biologic drug product for injection with a novel autoinjector concept.Drug delivery and translational research · 2025Article
- Thermodynamic Origin of the Linear Pressure Dependence of DNA Thermal Stability.The journal of physical chemistry letters · 2024Article
- Pressure Tuning Studies of Four-Stranded Nucleic Acid Structures.International journal of molecular sciences · 2023Review
- The Pressure Dependence of the Stability of the G-quadruplex Formed by d(TGGGGT).Life (Basel, Switzerland) · 2022Article
- Biomolecules under Pressure: Phase Diagrams, Volume Changes, and High Pressure Spectroscopic Techniques.International journal of molecular sciences · 2022Review
- Structural Responses of Nucleic Acids to Mars-Relevant Salts at Deep Subsurface Conditions.Life (Basel, Switzerland) · 2022Article
- G-quadruplexes in helminth parasites.Nucleic acids research · 2022Article
- Hidden intermediates in Mango III RNA aptamer folding revealed by pressure perturbation.Biophysical journal · 2022Article
- Volumetric Properties of Four-Stranded DNA Structures.Biology · 2021Review
- Nucleic Acid Catalysis under Potential Prebiotic Conditions.Chemistry, an Asian journal · 2020Review
- G-Quadruplexes as An Alternative Recognition Element in Disease-Related Target Sensing.Molecules (Basel, Switzerland) · 2019Review
- Exploring the effects of cosolutes and crowding on the volumetric and kinetic profile of the conformational dynamics of a poly dA loop DNA hairpin: a single-molecule FRET study.Nucleic acids research · 2019Article
- Pressure modulates the self-cleavage step of the hairpin ribozyme.Nature communications · 2017Article
- Delivery of cell-penetrating peptide-peptide nucleic acid conjugates by assembly on an oligonucleotide scaffold.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pressure is a thermodynamic parameter that can induce structural changes in biomolecules due to a volumetric decrease. Although most proteins are denatured by pressure over 100 MPa because they have the large cavities inside their structures, the double-stranded structure of DNA is stabilized or destabilized only marginally depending on the sequence and salt conditions. The thermal stability of the G-quadruplex DNA structure, an important non-canonical structure that likely impacts gene expression in cells, remarkably decreases with increasing pressure. Volumetric analysis revealed that human telomeric DNA changed by more than 50 cm3 mol-1 during the transition from a random coil to a quadruplex form. This value is approximately ten times larger than that for duplex DNA under similar conditions. The volumetric analysis also suggested that the formation of G-quadruplex DNA involves significant hydration changes. The presence of a cosolute such as poly(ethylene glycol) largely repressed the pressure effect on the stability of G-quadruplex due to alteration in stabilities of the interactions with hydrating water. This review discusses the importance of local perturbations of pressure on DNA structures involved in regulation of gene expression and highlights the potential for application of high-pressure chemistry in nucleic acid-based nanotechnology.
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