ArticleBMJ open2013
Respiratory infections in preterm infants and subsequent asthma: a cohort study.
Article in BMJ open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The association between early-life respiratory infections and childhood asthma: a meta-analytic perspective.Frontiers in medicine · 2026Pooled it
- Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children.The European respiratory journal · 2022Pooled it
- Effectiveness of family-centered communication on caregiving ability and health outcomes in premature infants: a systematic review protocol.Systematic reviews · 2026Article
- Preterm Birth and Risk of Health Service Use, Morbidity, and Medication Needs at 5 Years.JAMA pediatrics · 2025Article
- Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma.World journal of pediatrics : WJP · 2024Article
- Risk factors for poorer respiratory outcomes in adolescents and young adults born preterm.Thorax · 2023Article
- Are Babies Born Preterm High-Risk Asthma Candidates?Journal of clinical medicine · 2023Review
- Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates.Science translational medicine · 2022Article
- Phagocyte extracellular traps in children with neutrophilic airway inflammation.ERJ open research · 2021Article
- Article
- Impact of Prematurity and Severe Viral Bronchiolitis on Asthma Development at 6-9 Years.Journal of asthma and allergy · 2020Article
- Predicting Lung Health Trajectories for Survivors of Preterm Birth.Frontiers in pediatrics · 2020Review
- Burden, Etiology, and Risk Factors of Respiratory Virus Infections Among Symptomatic Preterm Infants in the Tropics: A Retrospective Single-Center Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- The impact of respiratory viruses on lung health after preterm birth.European clinical respiratory journal · 2018Review
- The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review.Pediatric pulmonology · 2017Review
- Gestational age-specific associations between infantile acute bronchiolitis and asthma after age five.Paediatric and perinatal epidemiology · 2014Article
- A longitudinal study on early hospitalized airway infections and subsequent childhood asthma.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether gestational age modifies the association of airway infections that result in hospital admission during the first year after birth, with subsequent asthma risk after age 5 years.
settingHospital inpatients and a general population comparison group in Sweden followed for subsequent diagnoses in primary and secondary care.
participantsNational registers identified 42 334 children admitted to hospital for respiratory infection in their first year after birth during 1981-1995, individually matched with 211 594 children not admitted to hospital for infection during their first year. PRIMARY OUTCOME: Asthma diagnoses and prescribed asthma treatments after the age of 5 years identified through registers.
resultsCox regression was used to identify a HR (and 95% CI) of 1.51 (1.47 to 1.51) for the association of respiratory infection before 1 year of age with asthma after age 5 years, after adjustment for sex, gestational age, chronic lung disease, maternal asthma and maternal smoking. When stratified by gestational age (and with additional adjustment for birth weight), there is statistically significant effect modification by gestational age, with the highest magnitude asthma risk among those born with a gestational age of less than 28 weeks, producing an adjusted HR of 2.22 (1.59 to 3.09). This higher magnitude asthma risk persisted until after age 10 years, but differences in risk by gestational age were less pronounced for asthma after age 16 years.
conclusionsExtremely preterm infants are most likely to have chronic respiratory sequelae following respiratory infections in early life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.