ArticleGenome biology and evolution2013
Whole genome and tandem duplicate retention facilitated glucosinolate pathway diversification in the mustard family.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 129 citations in OpenAlex.
- Polyploidization driven pan-genome structural remodeling and gene duplication mediated functional diversification in Panax.Functional & integrative genomics · 2026Article
- Dynamic evolution of FLC/MAF-like genes accompanying Brassicaceae radiation.Annals of botany · 2026Article
- High-quality genome assembly of Aglaia odorata reveals evolution, terpenes diversity and abundance in Meliaceae.Molecular horticulture · 2026Article
- Convergence and constraint in glucosinolate evolution across the Brassicaceae.The Plant cell · 2025Article
- Evolution of plant metabolism: the state-of-the-art.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Polyploids of Brassicaceae: Genomic Insights and Assembly Strategies.Plants (Basel, Switzerland) · 2024Review
- The Gynandropsis gynandra genome provides insights into whole-genome duplications and the evolution of C4 photosynthesis in Cleomaceae.The Plant cell · 2023Article
- Genome-Wide Identification and Expression Analysis of Calmodulin-Like Gene Family inCurrent issues in molecular biology · 2023Article
- Transcriptomic and metabolomic characterization of antibacterial activity ofFrontiers in plant science · 2023Article
- Combined genomic and transcriptomic analysis reveals the contribution of tandem duplication genes to low-temperature adaptation in perennial ryegrass.Frontiers in plant science · 2023Article
- Unlocking plant metabolic diversity: A (pan)-genomic view.Plant communications · 2022Review
- Insights into glucosinolate accumulation and metabolic pathways in Isatis indigotica Fort.BMC plant biology · 2022Article
- Genome-wide analysis of tandem duplicated genes and their expression under salt stress in seashore paspalum.Frontiers in plant science · 2022Article
- Evaluating domestication and ploidy effects on the assembly of the wheat bacterial microbiome.PloS one · 2021Article
- Genome-Wide Duplication of AllotetraploidG3 (Bethesda, Md.) · 2020Article
- Drivers of metabolic diversification: how dynamic genomic neighbourhoods generate new biosynthetic pathways in the Brassicaceae.The New phytologist · 2020Article
- Temporal patterns of diversification in Brassicaceae demonstrate decoupling of rate shifts and mesopolyploidization events.Annals of botany · 2020Article
- Genomic Blocks inFrontiers in plant science · 2020Article
- Genomic Origin and Diversification of the Glucosinolate MAM Locus.Frontiers in plant science · 2020Article
- Genome Improvement and Genetic Map Construction forG3 (Bethesda, Md.) · 2019Article
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5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants share a common history of successive whole-genome duplication (WGD) events retaining genomic patterns of duplicate gene copies (ohnologs) organized in conserved syntenic blocks. Duplication was often proposed to affect the origin of novel traits during evolution. However, genetic evidence linking WGD to pathway diversification is scarce. We show that WGD and tandem duplication (TD) accelerated genetic versatility of plant secondary metabolism, exemplified with the glucosinolate (GS) pathway in the mustard family. GS biosynthesis is a well-studied trait, employing at least 52 biosynthetic and regulatory genes in the model plant Arabidopsis. In a phylogenomics approach, we identified 67 GS loci in Aethionema arabicum of the tribe Aethionemae, sister group to all mustard family members. All but one of the Arabidopsis GS gene families evolved orthologs in Aethionema and all but one of the orthologous sequence pairs exhibit synteny. The 45% fraction of duplicates among all protein-coding genes in Arabidopsis was increased to 95% and 97% for Arabidopsis and Aethionema GS pathway inventory, respectively. Compared with the 22% average for all protein-coding genes in Arabidopsis, 52% and 56% of Aethionema and Arabidopsis GS loci align to ohnolog copies dating back to the last common WGD event. Although 15% of all Arabidopsis genes are organized in tandem arrays, 45% and 48% of GS loci in Arabidopsis and Aethionema descend from TD, respectively. We describe a sequential combination of TD and WGD events driving gene family extension, thereby expanding the evolutionary playground for functional diversification and thus potential novelty and success.
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