ArticleStem cells and development2014
Aldehyde dehydrogenase activity enriches for proximal airway basal stem cells and promotes their proliferation.
Article in Stem cells and development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- MI-181 enhances ciliation and cilia length in a cigarette smoke exposed airway epithelial model.Scientific reports · 2026Article
- Unflavored electronic cigarette exposure induces alterations in airway ciliary structure and function.Respiratory research · 2025Article
- Optimization of a micro-scale air-liquid-interface model of human proximal airway epithelium for moderate throughput drug screening for SARS-CoV-2.Respiratory research · 2025Article
- Gene expression during the formation of resting spores induced by nitrogen starvation in the marine diatom Chaetoceros socialis.BMC genomics · 2023Article
- Review
- Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.Nature medicine · 2021Article
- Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response.Cell stem cell · 2020Article
- Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging.Cell stem cell · 2020Article
- ALDH1A3 Regulations of Matricellular Proteins Promote Vascular Smooth Muscle Cell Proliferation.iScience · 2019Article
- Aldehyde dehydrogenase activity of Wharton jelly mesenchymal stromal cells: isolation and characterization.Cytotechnology · 2019Article
- Heterogeneity of Pulmonary Stem Cells.Advances in experimental medicine and biology · 2019Review
- Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic Fibrosis.Frontiers in pharmacology · 2019Review
- Depletion of Airway Submucosal Glands and TP63American journal of respiratory and critical care medicine · 2018Article
- Foreskin-derived mesenchymal stromal cells with aldehyde dehydrogenase activity: isolation and gene profiling.BMC cell biology · 2018Article
- Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.Respiratory research · 2017Article
- Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma.Journal of Cancer · 2017Article
- Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands.Stem cells (Dayton, Ohio) · 2016Article
- Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Progenitor cells in proximal airway epithelial development and regeneration.Journal of cellular biochemistry · 2014Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Both basal and submucosal gland (SMG) duct stem cells of the airway epithelium are capable of sphere formation in the in vitro sphere assay, although the efficiency at which this occurs is very low. We sought to improve this efficiency of sphere formation by identifying subpopulations of airway basal stem cells (ABSC) and SMG duct cells based on their aldehyde dehydrogenase (ALDH) activity. ALDH(hi) ABSCs and SMG duct cells were highly enriched for the population of cells that could make spheres, while the co-culture of ALDH(hi) differentiated cells with the ALDH(hi) ABSCs increased their sphere-forming efficiency. Specific ALDH agonists and antagonists were used to show that airway specific ALDH isozymes are important for ABSC proliferation. Pathway analysis of gene expression profiling of ALDH(hi) and ALDH(lo) ABSCs revealed a significant upregulation of the arachidonic acid (AA) metabolism pathway in ALDH(hi) ABSCs. We confirmed the importance of this pathway in the metabolism of proliferating ALDH(hi) ABSCs using bioenergetics studies as well as agonists and antagonists of the AA pathway. These studies could lead to the development of novel strategies for altering ABSC proliferation in the airway epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.