ArticleDento maxillo facial radiology2013
A retrospective study of digital subtraction technique to detect sclerotic changes in alveolar bone on intraoral radiographs of bisphosphonate-treated patients.
Article in Dento maxillo facial radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Early imaging signs of the use of antiresorptive medication and MRONJ: a systematic review.Clinical oral investigations · 2020Pooled it
- Radiomics-based classification of medication-related osteonecrosis of the jaw using panoramic radiographs.Oral radiology · 2025Article
- Imaging Modalities in Medication-Related Osteonecrosis of the Jaw: A Narrative Review of Diagnostic Findings and Staging.Medicina (Kaunas, Lithuania) · 2025Review
- Quantitative Segmentation Analysis of the Radiological Changes by Using ITK-SNAP: Risk Assessment of the Severity and Recurrence of Medication-related Osteonecrosis of the Jaw.International journal of medical sciences · 2021Article
- New Oral Surgery Materials for Bone Reconstruction-A Comparison of Five Bone Substitute Materials for Dentoalveolar Augmentation.Materials (Basel, Switzerland) · 2020Article
- Detecting the earliest radiological signs of bisphosphonate-related osteonecrosis.British dental journal · 2018Review
- Radiographic evidence of treatment with bisphosphonates.British dental journal · 2017Article
- Are there any differences in mandibular morphology of patients with bisphosphonate-related osteonecrosis of jaws?: a case-control study.Dento maxillo facial radiology · 2016Article
- Mandibular inferior cortical bone thickness on panoramic radiographs in patients using bisphosphonates.Oral surgery, oral medicine, oral pathology and oral radiology · 2015Article
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3 authors at 2 institutions in 1 country.
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Abstract
objectivesSeveral reports have suggested that sclerotic changes in cancellous bone of the jaw and thickening of the lamina dura are characteristic radiographic changes of an early silent stage of bisphosphonate (BP)-related osteonecrosis of the jaw. No quantitative evaluation has been reported to support this hypothesis. Emago(®) software (Oral Diagnostic Systems, Amsterdam, Netherlands) can perform digital subtraction on intraoral radiographs even if they were obtained by non-standardized radiography, provided the dimensional error is within a certain limit. The purpose of this study was to evaluate whether sclerotic changes of alveolar bone or thickening of lamina dura in patients using BP can be detected using the subtraction function of Emago.
methodsThe authors selected 46 pairs of intraoral radiographs of the mandibular molar area in dental patients. All radiographs were obtained at intervals of 6 months or more. Among the 46 pairs, 7 pairs were from patients who were being treated with BP (study subjects), and 39 pairs were from patients who had not been using BP (controls). All pairs of radiographs underwent digital subtraction by Emago. The number of pixels of the sclerotic areas was counted and compared between subjects and controls.
resultsThe sclerotic changes were significantly distinguishable in two of the seven subjects (28.6%) using BP.
conclusionsDigital subtraction function of Emago was able to detect sclerotic changes in alveolar bone. Therefore, it is suggested that the subtraction function of Emago is a useful tool for quantitatively detecting sclerotic changes that are observed at an early, silent stage of BP-related osteonecrosis of the jaw.
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