ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Association between cerebellar gray matter volumes, gait speed, and information-processing ability in older adults enrolled in the Health ABC study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03333837 (IMOVE), which is not on this map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
IMOVE: Improvisational Movement for People With Memory Loss and Their Caregivers
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.Aging clinical and experimental research · 2021Pooled it
- The brain map of gait variability in aging, cognitive impairment and dementia-A systematic review.Neuroscience and biobehavioral reviews · 2017Pooled it
- Exercise induces structural brain changes and elevates irisin levels and enhances functional performance in multiple sclerosis a pilot randomized study.Scientific reports · 2026Trial
- Characteristics for gait parameters of community-dwelling elderly Japanese with lower cognitive function.PloS one · 2019Trial
- A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Trial
- Association between cerebrospinal fluid volume and frailty in community-dwelling older adults: a cross-sectional study.Fluids and barriers of the CNS · 2026Article
- Age-related and dual task-induced gait alterations and asymmetry: optimizing the Semmelweis Study gait assessment protocol.GeroScience · 2025Article
- Adhering to Healthy Dietary Patterns Prevents Cognitive Decline of Older Adults with Sarcopenia: The Mr. OS and Ms. OS Study.Nutrients · 2025Article
- Reproductive health history and later life cognition in African Caribbean women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cerebellar Brain Inhibition and Its Association with Motor Inhibition and Reaction Time In Younger and Older Adults.Cerebellum (London, England) · 2025Article
- Relationship of Multiple Sensory Impairments With Physical Performance in Older Adults in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Cognitive cerebellum dominates motor cerebellum in functional decline of older adults with mild cognitive impairment.PloS one · 2025Article
- Article
- Associations of Neurological Biomarkers in Serum With Gait Measures: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Consensus Paper: Cerebellum and Ageing.Cerebellum (London, England) · 2024Review
- Amyloid-β Deposition Predicts Grocery Shopping Performance in Older Adults Without Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Examining the intersection of cognitive and physical function measures: Results from the brain networks and mobility (B-NET) study.Frontiers in aging neuroscience · 2023Article
- Energetic Cost of Walking and Brain Atrophy in Mid-to-Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Gait subgroups among older adults with chronic pain differ in cerebellum and basal ganglia gray matter volumes.Experimental gerontology · 2022Article
- The functional and structural neural correlates of dynamic balance impairment and recovery in persons with acquired brain injury.Scientific reports · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe cerebellum plays an important role in mobility and cognition. However, it is unclear which regions of the cerebellum are associated with gait speed and information-processing ability in older adults without overt brain damage.
methodsCross-sectional associations between cerebellar gray matter volumes (GMV), gait speed, and information-processing ability were explored in 231 community-dwelling adults (mean age: 83 years, 48% black, 58% female). We measured gait speed on an automated walkway and information-processing ability on the Digit Symbol Substitution test (DSST). Total and regional cerebellar GMV was measured on 3T-magnetic resonance imaging. Lobar GMV of the cerebellum, obtained by an automated parcellation process, were aggregated based on the cognitive (lobules VI, VII, VIII and crus I, II), sensorimotor (lobules II, IV, V), and vestibular (lobules IX and X) functions ascribed to the cerebellar regions.
resultsLarger cerebellar GMV correlated with faster gait speed and superior DSST scores (both p < .001) independent of age, gender, atrophy, and small vessel disease. After adjusting for age, gender, and atrophy, larger cognitive cerebellar GMV correlated with both faster gait speed (p = .04) and higher DSST scores (p < .001), larger sensorimotor cerebellar GMV correlated significantly with DSST alone (p = .02), and the vestibular cerebellar GMV with neither. The association between cognitive cerebellar GMV and gait speed was no longer significant after adjusting for DSST score in the linear regression models.
conclusionsThe relationship between gait speed and cerebellar GMV is influenced by information-processing ability, and this relationship is stronger in subregions ascribed to cognitive than vestibular or sensorimotor functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.