ArticleCirculation2013
High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.
Article in Circulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 108 citations in OpenAlex.
- Two-week step-reduction has limited negative effects on physical function and metabolic health in older adults.European journal of applied physiology · 2024Trial
- Small-protein Enrichment Assay Enables the Rapid, Unbiased Analysis of Over 100 Low Abundance Factors from Human Plasma.Molecular & cellular proteomics : MCP · 2019Trial
- Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk.Metabolism: clinical and experimental · 2014Trial
- Effects of Ulva prolifera polysaccharide calcium on flavor compound deposition, myofiber conversion and gut microbiota profiles in broilers.Science China. Life sciences · 2026Article
- Free Fatty Acids Carried by Lipoproteins: Revisiting the Overlooked Cargo.Acta physiologica (Oxford, England) · 2026Review
- Association of baseline and cumulative CHG index with risk of new-onset sarcopenia in middle-aged and older adults.The journal of nutrition, health & aging · 2026Article
- Association Between High-Density Lipoprotein Cholesterol Levels and Sarcopenia in Elderly Koreans.Journal of clinical medicine · 2025Article
- Identification of Plasma Free Fatty Acid Carrier Proteins in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Article
- Relationship between uric acid to high-density lipoprotein cholesterol ratio and sarcopenia in NHANES: exploring the mediating role of bilirubin and association with all-cause mortality.Frontiers in nutrition · 2025Article
- The PTK2B gene is associated with obesity, adiposity, and leptin levels in children and adolescents.iScience · 2024Article
- Exercise improves muscle mitochondrial dysfunction-associated lipid profile under circadian rhythm disturbance.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024Article
- High-density lipoprotein in diabetes: Structural and functional relevance.Journal of diabetes investigation · 2024Review
- Evidence That Skeletal Muscles Modulate HDL-Cholesterol in Metabolic Healthy Young Adults.Nutrients · 2024Observational
- HDL-C and apolipoprotein A-I are independently associated with skeletal muscle mitochondrial function in healthy humans.American journal of physiology. Heart and circulatory physiology · 2024Article
- New Player in an Old Field? Ecto-FArteriosclerosis, thrombosis, and vascular biology · 2024Article
- Article
- Impact of stress hyperglycemia ratio, derived from glycated albumin or hemoglobin A1c, on mortality among ST-segment elevation myocardial infarction patients.Cardiovascular diabetology · 2023Article
- Multimodal Imaging of Pancreatic Cancer Microenvironment in Response to an Antiglycolytic Drug.Advanced healthcare materials · 2023Article
- GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.Cardiovascular diabetology · 2023Article
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Authors and funding
24 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundAbnormal glucose metabolism is a central feature of disorders with increased rates of cardiovascular disease. Low levels of high-density lipoprotein (HDL) are a key predictor for cardiovascular disease. We used genetic mouse models with increased HDL levels (apolipoprotein A-I transgenic [apoA-I tg]) and reduced HDL levels (apoA-I-deficient [apoA-I ko]) to investigate whether HDL modulates mitochondrial bioenergetics in skeletal muscle. METHODS AND
resultsApoA-I ko mice exhibited fasting hyperglycemia and impaired glucose tolerance test compared with wild-type mice. Mitochondria isolated from gastrocnemius muscle of apoA-I ko mice displayed markedly blunted ATP synthesis. Endurance capacity during exercise exhaustion test was impaired in apoA-I ko mice. HDL directly enhanced glucose oxidation by increasing glycolysis and mitochondrial respiration rate in C2C12 muscle cells. ApoA-I tg mice exhibited lower fasting glucose levels, improved glucose tolerance test, increased lactate levels, reduced fat mass, associated with protection against age-induced decline of endurance capacity compared with wild-type mice. Circulating levels of fibroblast growth factor 21, a novel biomarker for mitochondrial respiratory chain deficiencies and inhibitor of white adipose lipolysis, were significantly reduced in apoA-I tg mice. Consistent with an increase in glucose utilization of skeletal muscle, genetically increased HDL and apoA-I levels in mice prevented high-fat diet-induced impairment of glucose homeostasis.
conclusionsIn view of impaired mitochondrial function and decreased HDL levels in type 2 diabetes mellitus, our findings indicate that HDL-raising therapies may preserve muscle mitochondrial function and address key aspects of type 2 diabetes mellitus beyond cardiovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.